If you take the entire north american continent, maybe. Although the numbers are in dispute, the indian population of north america probably numbered around ten million with the great bulk of the pre-european settlement indian population of it in central america. North of the Rio Grande, the Indian population most likely didn't number over a few million. Hunter-gatherer societies simply do not generate mass amounts of people. The europeans who settled the land north of the Rio Grande faced a virtually uninhabited land for the most part. In fact, the land west of the Missouri River and east of the Sierra Nevadas, is still largely unpopulated.
But I think I was referring to THE AMERICAS, and just Mexico probably had nearer 50 million than not.