I tried Google and was unable to find any JAMA article concerning peanut oil in vaccines. Could you post the Title or other particulars (issue, date, etc) please?
JAMA 2001 Apr 4;285(13):1746-8 Detection of peanut allergens in breast milk of lactating women states, “Most individuals who react to peanuts do so on their first known exposure”……………..and concluded “Peanut protein is secreted into breast milk of lactating women following maternal dietary ingestion. Exposure to peanut protein during breastfeeding is a route of occult exposure that may result in sensitization of at-risk infants.” PMID 11277829
Women have been ingesting peanut protein while breastfeeding for decades. What has changed in the last 15 years to cause infants to develop life-threatening allergies to this legume? One change has been the vaccination schedule.
The Int Arch Allergy Immunol 1999 Jul; 119(3):205-11 Pertussis adjuvant prolongs intestinal hypersensitivity concludes: Our findings indicate nanogram quantities of PT (pertussis toxin), when administered with a food protein, result in long-term senitization to the antigen, and altered intestinal neuroimmune function. These data suggest that exposure to bacterial pathogens may prolong the normally transient immune responsiveness to inert food antigens. PMID 10436392
Does this study explain why babies and toddlers react on their first exposure to the peanuts or other antigens? The babies may have been sensitized by the vaccines to the proteins through breast milk or formula ingested at the time of vaccination. This would also explain why children are anaphylactic to a variety of proteins, such as different tree nuts, peanuts, egg, legumes, milk, seeds, etc., depending on what proteins the mother ate at the time of vaccination.
Rates of anaphylaxis have increased dramatically since the introduction of the Hib vaccine.
Clin Exp Pharmacol Physiol 1979 Mar-Apr;6(2):139-49 Comparison of vaccination of mice and rats with Haemophilus influenzae and Bordetella pertussis as models of atopy, states “The Haemophilus influenzae vaccinated experimental animal provides a model that is possibly more related to human atopy than the Bordetella pertussis vaccinated animal.” PMID 311260
Ann Allergy 1979 Jan;42(1):36-40 states “To determine whether Haemophilus influenzae could be a factor in human atopy its effects were studied on the (para-)Sympathic Cyclic nucleotide-histamine axis in rats. Haemophilus influenzae vaccination induced changes in the cholinergic system compatible with higher cyclic GMP levels and enhanced histamine release. The authors suggest an involvement of the cholinergic system in Haemophilus influenzae vaccination effects. PMID 216288
Agents Actions 1984 Oct;15(3-4):211-5 entitled Bronchial hyperreactivity to histamine induced by Haemophilus influenzae vaccination states “……This suggests a hyperreactivity of the parasympathethic, cholinergic pathways as a result of H.influenzae vaccination.” PMID 6335351
Eur J. Pharmacol 1980 Apr 4;62(4):261-8 entitled The effects of Haemophilus influenzae vaccination on anaphylactic mediator release and isoprenaline-induced inhibition of mediator release states “These results indicate an increased sensitivity to antigenic challenge and suggest that the functioning of beta-adrenoceptors was decreased as a result of H. Influenzae vaccination.” PMID 6154589
DOES THE PERTUSSIS VACCINE CAUSE ASTHMA, ALLERGIES AND ANAPHYLAXIS?
Pediatrics 1988 Jun (81) Supplement - Report on the Task Force on Pertussis and Pertussis Immunization – extract states, For more than 25 years, it has been known that pertussis vaccine is a reliable adjuvant for the production of experimental allergic encephalitis.4
Bull Eur Physiopathol Respir 1987;23 Suppl 10:111s-113s A model for experimental asthma: provocation in guinea-pigs immunized with Bordetella pertussis states, “ Guinea-pigs were sensitized with killed Bordetella pertussis………the presence of the immediate type of immune response was verified by passive cutaneous anaphylaxis……B. pertussis not only alters adrenergic function but provocation in B. pertussis-sensitized guinea-pigs seems to be a good model for bronchial asthma. PMID 2889487
Pediatr Res 1987 Sep;22(3):262-7 Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction……….the results of our experiments have established that the disease induced by coimmunizing mice with Ptx and BSA is due to an immediate type hypersensitivity…………PMID 3309858
Infect Immun 1987 Apr.;55(4):1004-8 Anaphylaxis or so-called encephalopathy in mice sensitized to an antigen with the aid of pertussigen (pertussis toxin), states, Sensitization of mice with 1mg of bovine serum albumin (BSA) or chicken egg albumin (EA) ………….induced a high degree of anaphylactic sensitivity when the mice were challenged i.v. with 1 mg of antigen 14 days later. PMID 3557617
JAMA 1994 Aug 24-31;272(8):592-3 Pertussis vaccination and asthma: is there a link?
A study of 450 children, 11% of the children who had received the pertussis vaccination suffered from asthma, as compared with only 2% of the children who had not been vaccinated. PMID 8057511
Allergy 1983 May;38(4):261-71
The non-specific enhancement of allergy. III. Precipitation of bronchial anaphylactic reactivity in primed rats by injection of alum or B. pertussis vaccine: relation of response capacity to IgE and IgG2a antibody levels. …..These results show that injection of alum or B. pertussis vaccine without antigen can precipitate/enhance anaphylactic response capacity and production of specific and non-specific IgE and IgG2a. PMID 6307077