They should, as many are doing, reject unconstitutional laws first in the courts and then by stronger efforts if the courts fail to sustain them. Personally I don’t think it will come to that.
I will say that their efforts would be very much easier if the 17th amendment were not on place and the various state legislatures still had power over the senate.
The last time that was tried in 1957, President Eisenhower sent the 101st Airborne Division to Little Rock with bayonets drawn and orders to kill white American citizens if they dared to raise their hands in defiance to federal authority.
I would run on and maintain a platform where I would swear to uphold the best interests of my State (FL), by regularly meeting with my State’s Legislature and Governor, on all matters presented in the US Senate.
But, then again, as my dad used to say...
“If we had some ham, we could have some ham and eggs, if we had some eggs”
...that is all