If it turns out that she quit to prepare for a presidential run, that would make it a good move in my book. I think most reasonable people would agree.
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If it turns out that, as you suggest, she quit to prepare for a run at the WH it would mean that the excuses she gave were lies. It would mean that her oath of office was trumped by ambition. It would give the msm a genuine "do you mean what you say now or did you mean what you said before?" angle of attack.
I think that most reasonable people would agree.