Wee need to get rid of tenureship. It’s a mechanism that allows dictatorial academic control by the left in our universities. It’s one of the things that convinced me not to finish my dissertation and seek an academic career. It has become a weapon for the left and we need to remove it from their hands...
Huh....who da thunk?
Dr. Amy Bishop - Alabama University - Rate My Professor!
http://www.ratemyprofessors.com/ShowRatings.jsp?tid=392617&page=3
She went nuts.
She shot her tenure board members.
They must have done her real dirty, IMHO.
The perp’s ‘curriculum vitae’:
http://74.125.47.132/search?q=cache:mh0wewGP7gwJ:www.uah.edu/biology/amy.html+dr.+amy+bishop&cd=1&hl=en&ct=clnk&gl=us&client=firefox-a
__________________________________________________________
Dr. Amy Bishop
Assistant Professor
Department of Biological Sciences
Research Areas
# Molecular Biology of Oxidative Stress
# Neurobiology
# Neuroengineering
# Induced Adaptive Resistance
Research Description
Molecular Biology of Oxidative Stress
I have had a longstanding interest in the free radical gas, nitric oxide (NO), and its role in the central nervous system (CNS). Nitric oxide, originally discovered as an environmental pollutant, is synthesized at physiological levels by many mammalian cells and is utilized for a variety of functions such as signal transduction for cell signaling, for cellular differentiation, and for neurotransmission in learning and memory. At a high flux rate, such as that released by immune cells, or when released out of context in a stressed environment, it has been established that NO is toxic. NO-mediated damage is implicated in the cell death of motor neurons and their support cells, oligodendrocytes, during CNS injury (stroke or spinal transection) and during degenerative disease, such as Amyotrophic Lateral Sclerosis (ALS), and Multiple Sclerosis (MS).
There are many proposed mechanisms and cellular targets of NO damage with the major target being protein. High flux NO can disrupt heme-containing proteins and cause them to release heme into the intracellular environment. This has been proposed to result in iron-mediated generation of reactive nitrogen species, namely peroxynitrite. NO, when combined with other oxidants in the cell, forms peroxynitrite which goes on to nitrate tyrosine residues, thereby disrupting protein structure and function. Nitrotyrosine (3NY) positive aggregates are seen in spinal injury and are found in the motor neurons of ALS patients and in the plaques seen in MS patients. Due to my research, and that of others, nitrotyrosine (3NY) is now regarded as a quantifiable marker for NO-mediated damage in the CNS.
Induced Adaptive Resistance
Nitric oxide released at physiological levels plays a variety of beneficial roles, while at high doses or during pathological circumstances NO becomes toxic. I have proposed that normal cellular resistance mechanisms are defective, in the case of CNS disease, or overwhelmed, in the case of CNS injury. Is it possible that these normal resistance mechanisms can be “primed” against oxidative insult by a pretreatment dose of a lower concentration of that oxidant? Specifically, I have asked if a low dose of NO can prepare a cell for subsequent toxic challenge of NO or other oxidants. In fact, I have discovered that cells pretreated with low levels of NO become resistant to toxic levels of NO and other oxidants. This phenomenon, Induced Adaptive Resistance (IAR), is dependent on hemoxygenase1 (HO1), a heme-metabolizing enzyme.
Neuroengineering
My laboratory’s goal will be to continue in our effort to develop a neural computer, the Neuristor™, using living neurons. This computer will exploit all of the advantages of neurons. Specifically, neurons rich with the nitric oxide (NO) dependent learning receptor, N Methyl D Aspartate receptor (NMDAR), will be utilized. These have previously been studied in the context of induced adaptive resistance to NO (IAR). For the Neuristor™ we will take advantage of the IAR phenomena since it has been demonstrated that IAR neurons express more learning and memory receptors (NMDAR) as well as increased neurite outgrowth. The neurons that we are currently using are mammalian motor neurons. We are exploring the possibility of using neurons derived from adult stem cells, and from bony fishes provided by Bruce Stallsmith Ph.D. This laboratory has created a portable cell culture incubator, the Cell Drive™ that is an ideal support structure for the Neuristor™.
Most Recent Publications
Anderson, L. B., Anderson P. B., Anderson T. B., Bishop A., Anderson J., Effects of selective serotonin reuptake inhibitors on motor neuron survival (2009) International Journal of General Medicine. In press
Bishop A., Green-Hobbs K., Eguchi A., Pennie C., Anderson J.E., Estévez A. Differential sensitivity of oligodendrocytes and motor neurons to reactive nitrogen species: a new paradigm for the etiology of Multiple Sclerosis (2009). Journal of Neurochemistry. (109) 93-104.
Bishop A, Gooch R, Green-Hobbs K, Cashman N. R., Demple B., Anderson J. E., Estévez A.,. Mitigation of nitrotyrosine formation in motor neurons adapted to nitrooxidative stress. (2009) Journal of Neurochemistry. (109) 74-84.
Bishop A., Gooch R., Anderson J., Induced Adaptive Resistance to Nitrooxidative Stress in the CNS: Therapeutic Implications (2006) Current Medicinal Chemistry - Central Nervous System Agents 6(4).
Bishop A. & Anderson J. (2005). NO signaling in the CNS: From the Physiological to the Pathological. TOXICOLOGY (208):193-205.
Amy Bishop, Shaw Fung-Yet, Mark J. Perrella, Arthur M. Lee, Neil R. Cashman & Bruce Demple (2004) A key role for heme oxygenase-1 in nitric oxide resistance in murine motor neurons and glia. BBRC 325:3-9.
Amy Bishop, Neil R. Cashman. (2003) Induced adaptive resistance to oxidative stress in the CNS: Discussion of possible mechanisms and their therapeutic potential. Current Drug Metabolism 4(2) 171-184.
Complete List of Publications
Courses Taught at UAH
BYS 313: Anatomy & Physiology 1
BYS 314: Anatomy & Physiology 2
BYS 400/600: Introduction to Neuroscience
Special Topics 691: Mechanisms of resistance to oxidative stress in the CNS
Special Topics 692: Research
Very interesting to see this is not the first time she has murdered. What’s up with those records disappearing?
http://www.foxnews.com/story/0,2933,585781,00.html
People kill People, not the gun. What a shame that someone can actually take another person’s life. Our Lord is coming soon.