"Hi I'm Simon from early 90's Saturday night live, I'm running to join Stuart Smalley in the US Senate. Me, my rubber ducky, and my right hand (whom I consider a separate entity from myself) have been involved in a polygamous union for the past ten years. Why am I being treated like a second class citizen?".
The GOP ran a tranny in Vermont against Bernie Sanders in 2000. He/she did worse than anyone who has ever run against Sanders.
I figure any Catholic dimrat voters who might be considering the RINO ticket would be turned off by Tisei. They are certainly much more numerous and malleable than gay voters.