Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Scientists discover influenza's Achilles heel: Antioxidants
Federation of American Societies for Experimental Biology ^ | 10-29-09 | Cody Mooneyhan

Posted on 10/29/2009 10:30:41 AM PDT by Pharmboy

New research in the FASEB Journal opens the door for new drugs that could prevent severe flu-related lung damage As the nation copes with a shortage of vaccines for H1N1 influenza, a team of Alabama researchers have raised hopes that they have found an Achilles' heel for all strains of the flu—antioxidants. In an article appearing in the November 2009 print issue of the FASEB Journal (http://www.fasebj.org) they show that antioxidants—the same substances found in plant-based foods—might hold the key in preventing the flu virus from wreaking havoc on our lungs.

"The recent outbreak of H1N1 influenza and the rapid spread of this strain across the world highlights the need to better understand how this virus damages the lungs and to find new treatments," said Sadis Matalon, co-author of the study. "Additionally, our research shows that antioxidants may prove beneficial in the treatment of flu."

Matalon and colleagues showed that the flu virus damages our lungs through its "M2 protein," which attacks the cells that line the inner surfaces of our lungs (epithelial cells). Specifically, the M2 protein disrupts lung epithelial cells' ability to remove liquid from inside of our lungs, setting the stage for pneumonia and other lung problems. The researchers made this discovery by conducting three sets of experiments using the M2 protein and the lung protein they damage. First, frog eggs were injected with the lung protein alone to measure its function. Second, researchers injected frog eggs with both the M2 protein and the lung protein and found that the function of the lung protein was significantly decreased. Using molecular biology techniques, scientists isolated the segment of the M2 protein responsible for the damage to the lung protein. Then they demonstrated that without this segment, the protein was unable to cause damage. Third, the full M2 protein (with the "offending" segment intact) and the lung protein were then re-injected into the frog eggs along with drugs known to remove oxidants. This too prevented the M2 protein from causing damage to the lung protein. These experiments were repeated using cells from human lungs with exactly the same results.

"Although vaccines will remain the first line of intervention against the flu for a long time to come, this study opens the door for entirely new treatments geared toward stopping the virus after you're sick," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "and as Thanksgiving approaches, this discovery is another reason to drink red wine to your health."

###

Receive monthly highlights from the FASEB Journal by e-mail. Sign up at http://www.faseb.org/fasebjournalreaders.htm. The FASEB Journal (http://www.fasebj.org) is published by the Federation of the American Societies for Experimental Biology (FASEB). The journal has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century and is the most cited biology journal worldwide according to the Institute for Scientific Information. FASEB comprises 22 nonprofit societies with more than 80,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB advances health and welfare by promoting progress and education in biological and biomedical sciences through service to its member societies and collaborative advocacy.

Details: Ahmed Lazrak, Karen E. Iles, Gang Liu, Diana L. Noah, James W. Noah, and Sadis Matalon. Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species. FASEB J. doi:10.1096/fj.09-135590 ; http://www.fasebj.org/cgi/content/abstract/23/11/3829


TOPICS: Culture/Society; Extended News; News/Current Events; US: Alabama
KEYWORDS: antioxidants; flu; h1n1; health; influenza; medicine; swineflu
Navigation: use the links below to view more comments.
first previous 1-2021-4041-44 last
To: madamemayhem
You: my mom has cancer and it is imperative to keep the “flu bugs” away. her home healthcare aide told us that if you cut an onion in half and put it near the entrance to the home, and half in each room, it will keep the flu at bay.

May I suggest that you consider adding 20,000+ units of Vitamin D3 (not D2) per day to your mom's daily regime. I work with urgent and primary care and we really believe that D3 is profoundly important to health. Not to mention it is dirt cheap!

We try to get all of our people and patients to take at least 10,000 units per day to boost their immune systems - all the time, not just for the flu season. We do believe that it offers protection against all types of flu and upper respiratory infections - both to help you avoid catching them and to help you survive them if you do.

While I don't what cancer your mom has or what stage she is, the benefits would good for all that she is dealing with. Watch the YouTube video below.

D3 will boost her immune system and has a very strong-anti cancer effect. In fact, D3 is involved in almost every system in the body and we need a lot more than we get. See Links below.

Your mother needs a therapeutic level of D3 in her body and you really can't overdo this. My mother is 86 and is in great shape. I started her on Vitamin D3 when evidence came out that it almost eliminates falling in older people. We went from a fall every couple of weeks to 0 falls in the last 2 years. She has been taking 15,000 units/day for the last 5 years. That sounds like a lot but it really is a tiny amount. 1,000 IU is equivalent to 0.025 mg—only 0.000025 of a gram!

I did just make my mom close her 60 year old ladies wear business. She drove there everyday, kept the books and did the buying, but this was for economic reasons, not her health. She would be better off working but this is not a great time for better womens apparel. She can just stay mad at me.

Supposedly you can get 20-30,000 units from 30 minute of sunshine. I doubt that your mom is getting much of that.

If she is not in good shape right now, you might consider giving her the 20,000+ units (yes, 40,000 units/day)twice a day for a few weeks - 2 or 3 - and then get her tested for her levels. The correct test your doctor needs to order is "25(OH)D"(this test and nothing else!) You will probably find that she is still low, but you can adjust the dose to get her to a therapeutic level (60 to 90.0 ng/mL) and maintain it. With cancer, I would shoot for the high side.

Not to muddy the water, but I do want to get this in here. If her Omega 3 levels, DHA and EPA, are not being maintained, she would benefit (a lot) from 9 grams of good quality fish oil per day. It sounds like a lot but it is 1 tablespoon and it takes that if she is sick.

Fish oil is a macro nutrient ie. food. 1 gram is just not going help her. The vitamin D and the fish oil might have impressive results in how she does and how she feels. Good luck!

Vitamin D and Swine Flu in Nursing Homes

Vitamin D and Cancer - UC at San Diego YouTube

The Uber Nutrient Worth Hundreds of Billions

PS. Do a Google on "curcumin cancer" on the web. You will find some very interesting new science coming out now.

PPS. You can use your onion for something else. ☺
41 posted on 10/29/2009 12:42:52 PM PDT by Ron/GA
[ Post Reply | Private Reply | To 12 | View Replies]

To: WVNan
Start googling. It's a fermented tea made with live cultures and enzymes. I'm somewhat of a fanatic about it now. I just gave my insurance salesman 3 bottles.

I am trying to get those who want to use it continuously to learn to brew their own.

There is lots of info about fermented foods and their health benefits.

I recall reading about kim chi curing bird flu. I started drinking this stuff and within a few weeks noticed my toe nail fungus was healing. I also put some in a little bottle with a tip on it and put some on my toes each am and pm.

I met someone in a health food store who told me that her hospital where she works was considering using kombucha as a disinfectant. It works by the good bacteria crowding out the bad bacteria.

This really is a fun hobby. I opened several bottles today with pieces of mango in it. I also have some ready that is mixed with cranberry juice.

Fortunately, I have two ovens so I have four gallons of this stuff brewing in one oven with just the light bulb providing a nice comfy constant temp for the kombucha.

42 posted on 10/29/2009 1:37:26 PM PDT by Conservativegreatgrandma (Al Franken--the face of the third-party voters)
[ Post Reply | Private Reply | To 34 | View Replies]

To: Oldhunk

My hubby and I are both in our 70s and neither of us take any medications. We don’t need any. I also love Ester C for any aches or pains.


43 posted on 10/29/2009 1:40:01 PM PDT by Conservativegreatgrandma (Al Franken--the face of the third-party voters)
[ Post Reply | Private Reply | To 39 | View Replies]

To: Ron/GA

thank you for the info. at this point she is not strong enough to withstand any traditional treatments. we have been researching alternative therapies and ran across curcumin and also capsaicin as very impressive cancer fighters. we are also looking into essiac tea. we accept what the worst could be, we work toward the best, and we pray for a miracle.


44 posted on 10/29/2009 8:12:42 PM PDT by madamemayhem (defeat isn't getting knocked down, it's not getting back up)
[ Post Reply | Private Reply | To 41 | View Replies]


Navigation: use the links below to view more comments.
first previous 1-2021-4041-44 last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson