Need more details -- at first blush this sounds like the Philadelphia chromosome; and as such, wouldn't it indicate that the daughter inherited the abnormality for the leukemia?
Secondly, I thought (again, at first blush, as a non-MD) that the lump in the neck sounded like Non-Hodgkin's lymphoma.
What gives?
Sorry the daughter lost her mom, too.
Secondly, I thought (again, at first blush, as a non-MD) that the lump in the neck sounded like Non-Hodgkin's lymphoma.
Here's the abstract:
Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally-derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion.