Not long ago people thought it was OK to smoke while pregnant, maybe earlier than that it could have been considered OK to drink. Knowledge suggests at times we adjust behaviors currently compared to the past.
Downs is one issue.
When he was old enough he would go to the swimming pool, take off his leg and jump in. He could not play football but he was the water boy or whatever they needed him to do. He is retired now and is a house husband and loves it. He does all the housework, cooking, etc and even cans fruit.
Everyone accepted him for the person he was and that was that.