Usually they are taken down before/during the Primary by the GOP establishment. They prefer Dems to Conservatives, apparently.
The sad thing is you can usually which candidate the RINO is if the GOP "leadership" intervenes in a primary and is hell-bent on making certain their chosen one is nominated. Arnold, Specter, Martinez, Chaffee, Crist...
And of course, whichever "Republican" official gets non-stop fawning allocates from the pro-Obama local media, while all their other endorsements are down-the-line pro-Democrat