Federalism as created by the US Constitution has been a complete failure. The anti-feds were correct. The federalists were woozy. I'd rather we'd have erred on the side of weak central gubmint, but that's water under the bridge now. We are one big megastate and nothing but Armageddon will undo it.
It's been made pretty clear throughout history that the weak central states get gobbled up by the stronger and if that had remained the case, we'd ALL be speaking Spanish or worse, French by now. The concept of federalism as practiced since 1790 was cited during both WWI & WWII by our enemies as a compelling reason to avoid invasion of our home soil. Words to the effect of facing fifty armies...
There have been eras when the concept worked well and the people prospered and didn't live in fear of the government. Of course none of those were under Democratic administrations or a Democrat Congress but this illustrates the point.
We completely agree on your final point: At this moment only Armageddon will undo the evil that has been wrought. The Four Horsemen of the Apocalypse began their journey in May of 1948 and the sound of their thundering hoofbeats grows ever more intense and closer.