Don't forget time-scale. Some of those extreme changes happened over thousands of years. (They look quick when the plot is millions of years long.)
I'm not even convinced we have the ability to make even small changes in the overall climate.
Do you think stratospheric ozone depletion is natural? Ozone depletion is about 50% of the reason that the stratosphere is cooling; the other 50% is caused by reduction of radiative warming due to increased tropospheric GHGs.
Frankly, I'd be interested to find out if the cosmic rays, the absence or presence of which seem to be a major force in the warming and cooling of the planet, are also having an effect on the production of ozone in our atmosphere.