Largest S&W I own is a 45 Colt Hunter from Performance shop. I use garretts in it for a while and it was tooooooooo hot for the n-frame. I own redhawk rugers, and a Linebaugh 500 Bisley built on a ruger. But I think my next effort will be a 454/45 super redhawk. Let Bowen do an action job for me, maybe tweek this or that and use that as a all round accessory while wheeling in dangerous game regions.
Wish Ruger would make a standard Redhawk in .454, even if it had to be a 5 shot.
(It IS Christmas season after all...)