What is taking so long is that there are so many papers on the subject of directed evolution of proteins evolving to tolerate heat that it is difficult to find that particular one where they covered every Single nucleotide polymorphism. Why do you deny that it is mathematically possible to do so, will me finding it change your opinion about anything?
How is this to tide you over; it shows how bacteria respond to stress by increasing its own mutation rate (now why would it want to do that?)....
Crit Rev Biochem Mol Biol. 2007 Sep-Oct;42(5):373-97. Links
Stress-induced mutagenesis in bacteria.Foster PL.
Department of Biology, Indiana University, Bloomington, Indiana 47405, USA. plfoster@indiana.edu
Bacteria spend their lives buffeted by changing environmental conditions. To adapt to and survive these stresses, bacteria have global response systems that result in sweeping changes in gene expression and cellular metabolism. These responses are controlled by master regulators, which include: alternative sigma factors, such as RpoS and RpoH; small molecule effectors, such as ppGpp; gene repressors such as LexA; and, inorganic molecules, such as polyphosphate. The response pathways extensively overlap and are induced to various extents by the same environmental stresses. These stresses include nutritional deprivation, DNA damage, temperature shift, and exposure to antibiotics. All of these global stress responses include functions that can increase genetic variability. In particular, up-regulation and activation of error-prone DNA polymerases, down-regulation of error-correcting enzymes, and movement of mobile genetic elements are common features of several stress responses. The result is that under a variety of stressful conditions, bacteria are induced for genetic change. This transient mutator state may be important for adaptive evolution.
PMID: 17917873 [PubMed - indexed for MEDLINE]
==Why do you deny that it is mathematically possible to do so, will me finding it change your opinion about anything?
No, I just want to read the entire study to make sure you didn’t miss any data or conclusions that might point to epigenetics or Creation.
I have to go for now. I’ll read the “tide you over” paper when I return.
All the best—GGG