Nuclear terrorism is a prospect too dreadful to contemplate. So is biological terrorism. One thing that we can 100% rely upon: as soon as an overtly maniac Muslim country gets any significant biological or nuclear capability, one or both of these will happen. Either in Israel or in the US or probably both.
It is risky enough that Pakistan is nuclear: they aren’t quite as whacked as Iran, but pretty close — it wouldn’t take much.
To me, a preemptive strike makes an eminent amount of sense. Select a useful target like Mecca or Tehran and level it, with a warning that more will happen with the very next display of monkeyshines. Then carry out that threat.
It is an ugly thought, the preemptive strike, and it would be politically very difficult to do. Europe, Russia, China — in fact the whole world — would scream blue murder.
What are the alternatives, tho’? Without a preemptive strike, a nuclear/biological terrorist attack is one day certain to happen.