Does it matter what sex they are?
lol, nope
If we're talking about someone with a gun or a knife who is within 10 or 15 feet of me, no it doesn't matter what sex they are! A demented woman with a knife can ruin your whole day (or week or life)!
I also "carry" on a regular and recurring basis; I will warn someone only once (if the opportunity allows) that I will "defend myself if necessary with lethal force". If they take th hint, I will let them walk away; if they don't, I will do as I've promised (and then call 911).