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Diabetes study halted after safety review reveals risk

Check USAToday. The aggressively treated folks had about 10% fewer non-fatal MIs, IIRC.

1 posted on 02/07/2008 8:03:29 PM PST by neverdem
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To: neverdem

There are SO MANY VARIABLES in human health.....and people with diabetes usually have OTHER problems.....


2 posted on 02/07/2008 8:06:59 PM PST by goodnesswins (Being Challenged Builds Character! Being Coddled Destroys Character!)
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To: neverdem

More confusing medical information.

It boggles the mind.


3 posted on 02/07/2008 8:07:54 PM PST by Mears
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To: neverdem

Cool, more ice cream!


4 posted on 02/07/2008 8:09:37 PM PST by mtbopfuyn (I think the border is kind of an artificial barrier - San Antonio councilwoman Patti Radle)
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To: austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; texas booster; ...
Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes

Confounding with the ACCORD results, go figure. Maybe there was a selection bias. Who knows?

Freepmail me if you want on or off of the diabetes ping list.

6 posted on 02/07/2008 8:16:48 PM PST by neverdem (I have to hope for a brokered GOP Convention. It can't get any worse.)
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To: neverdem
I'm a genetic Type II with a long history of coronary disease on Dad's side (he, his father, and two of his brothers were felled by it), and my doctor goes by the 'keep it under 7' A1C rule. I lost weight, starting working out faithfully (again) about three years ago, cut out refined sugars, and I'm healthier now than I've been in 20 years, plus I'm not popping Glucovance and sticking myself twice a day. I didn't need to turn vegan, change religions, or learn a secret handshake to do it - you just tweak around the edges until you get the desired effect, and quit worrying about dropping dead from a corollary affliction.


7 posted on 02/07/2008 8:22:21 PM PST by Viking2002 (Waterboarding the Left every chance I get.)
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To: neverdem

6.4% vs. 7.9%?? That can’t be right.

Could anyone convert that to mg/dL? (that’s milligrams per deciliter). My blood sugar meter is in those units.

As I recall, one pint of blood is about a pound.
One deciliter of blood would be about 466000 mg.
So by weight, 100 mg/dL looks to be about 0.02%.

Now the fasting level should be 80-100 mg/dL. However I don’t think my max is more than 0.1% by weight.

I can’t believe the proportions by volume would be vastly different.


8 posted on 02/07/2008 8:24:26 PM PST by scrabblehack
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To: IslandJeff

ping


9 posted on 02/07/2008 8:27:16 PM PST by metmom (Welfare was never meant to be a career choice.)
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To: neverdem

It looks like the intent of the study was to validate the notion that taking more insulin and medications in order to more tightly control blood glucose levels would be a good thing. The maroons did not bother to suspect that the negative effects of the extra insulin could outweigh the benefits of lower glucose. How about that! Insulin is known to be a killer and is responsible for the destruction of the fine capillaries everywhere.


16 posted on 02/07/2008 8:55:01 PM PST by kruss3 (Kruss3@gmail.com)
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To: neverdem

This is astonishing.


17 posted on 02/07/2008 8:56:14 PM PST by Dr. Scarpetta
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To: neverdem
This study is extremely flawed !

if the BS was lowered by insulin, no wonder the increase in heart conditions.

Too much Insulin will cause heart and feet and eye problems.

Some types of Type II is insulin resistance, if you add injected insulin it will cause all the problems.

However if you lower BS by diet and exercise it will not cause increased Heart, fee and eye problems.


19 posted on 02/07/2008 9:06:15 PM PST by Uri’el-2012 (you shall know that I, YHvH, your Savior, and your Redeemer, am the Elohim of Ya'aqob. Isaiah 60:16)
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To: neverdem

This result shouldn’t come as a surprise at all. For years, I have noted that people diagnosed with maturity-onset (Type II) diabetes see their health continue to decline despite medical treatment with drugs. If they live long enough, their dosages of diabetic meds eventually have to be increased, or different meds have to be given, and eventually many have to resort to insulin. In those same people, the same is true for their hypertension and high cholesterol meds. In other words, despite taking meds that normalize their blood sugar levels, blood pressure levels, and blood lipids, they continue to get sicker. The obvious implication of that is that the underlying problem that caused the high blood sugar, high cholesterol, and/or hypertension to begin with, has not been treated.
Most of the patients in this study probably were treated with insulin, or the classes of drugs that stimulate the body to make more insulin. Therein lies the problem. Treating Type II diabetes with insulin or insulin-producing drugs is like throwing gas on a fire to put it out, and more importantly, the underlying problem goes unaddressed.
The article discussing this study backs this up. Note the following from the article:
“Dr. John Buse, the vice-chairman of the study’s steering committee and the president of medicine and science at the American Diabetes Association, described what was required to get blood sugar levels low, as measured by a protein, hemoglobin A1C, which was supposed to be at 6 percent or less. ...Many were taking four or five shots of insulin a day,” he said. “Some were using insulin pumps. Some were monitoring their blood sugar seven or eight times a day. .. .They also took pills to lower their blood sugar, in addition to the pills they took for other medical conditions and to lower their blood pressure and cholesterol. ...Those assigned to the less stringent blood sugar control, an A1C level of 7.0 to 7.9 percent, had an easier time of it. They measured their blood sugar once or twice a day, went to the clinic every four months and took fewer drugs or lower doses.”

DUH. .. . It’s almost comic that the writer then states: “So it was quite a surprise when the patients who had worked so hard to get their blood sugar low had a significantly higher death rate, the study investigators said.”
Someone should clue these researchers in on the fact that Type II diabetes is not caused by insufficient insulin in the blood. In fact, Type II diabetics pump out EXCESS insulin in a futile effort to increase cell uptake of the stuff because of resistance at the cell wall. Giving Type II patients insulin, Glucophage, Tolinase, etc. is the gasoline added to the fire.


27 posted on 02/07/2008 9:46:52 PM PST by BuckeyeForever
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Japan to launch origami planes into outer space

HIV can be passed to babies in pre-chewed food

FReepmail me if you want on or off my health and science ping list.

Comment# 28 links another story about this ACCORD study on diabetes with unexpected results.

29 posted on 02/07/2008 10:02:32 PM PST by neverdem (I have to hope for a brokered GOP Convention. It can't get any worse.)
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To: neverdem

Thanks for the pings. Diabetes is a very complicated disease.


35 posted on 02/08/2008 8:28:33 AM PST by Freee-dame
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