[neverdem]

Disruption of Large-Scale Brain Systems in Advanced Aging

[Jeff Chandler]

I don’t understand a single word of this article.

[Abogado]

bump

[mylife]

All the other spark plugs start misfiring, why wouldn’t the one called the brain?

Guess we had better do a study

[Secret Agent Man]

I just wonder why they used 20-somethings. In previous posts about brain development it’s been noted that the brain isn’t really completely fully developed until about 25. If the 20-somethings were below 25, I wonder if that really is a good model of an adult brain. Perhaps adults of around 30 might be a better benchmark to get a real picture of how a fully developed, adult brain works.

[DeFault User]

Next they will find out why we geezers have the inexplicable urge to wear dark socks with shorts.

[umgud]

It’s great when you get so old you can’t do it anymore, but memory is so bad you thought you did.

[JennysCool]

I'm no brain scientist (although I have stayed at a Holiday Inn Express a couple of times), but I always wonder -- with all the technology we have now -- why a complete body scan on say a 50-year-old, and another on that same person at 75, wouldn't show something, some compound or nutrient, that has been added or subtracted in the intervening years, and might be what the 75-year-old with Alzheimers has or doesn't have compared with his profile 25 years earlier.

I mean, something has to be different.

[JoeSixPack1]

Gee, you get older and things stop working the way they did when you were younger.

Where’s my grant $$?

[neverdem]

The Role of Biomarkers in Clinical Trials for Alzheimer Disease

More recently, PET imaging studies using radioligands that bind directly to β-amyloid plaques have been performed.28,29 One of these ligands, Pittsburgh Compound-B (PIB), is a thioflavin derivative and appears to be relatively selective for β-amyloid plaques at the concentrations used for imaging studies. As shown in Figure 2, the binding of PIB to brain sections is highly correlated with total Aβ levels. Test/retest variability in clinical studies is less than 10% for most brain regions.30

[svcw]

I resent that just because I am 60 I can not remember things and am slowing down. I mean yesterday, I think it was yesterday but it could have been last week or I might be planning it for tomorrow and just think I remember, ok what was the post about.

[my_pointy_head_is_sharp]

Deteriorating white matter may turn out to be the root problem, breaking down communication links between brain regions and impairing their ability to work in a coordinated manner

I see this as one more step towards euthanasia of the elderly. The tests were done on twenty-somethings and on people 60 and above. I want to know the actual ages. Twenty-somethings is a 10-year range. But 60 and above could be a 40-year range!!!!!!! The 60's, the 70's, the 80's, and the 90's. What a shady test! Do you suppose they have an agenda???

[steve86]

Be interesting to see if statins postpone this degenerative process, or at least some aspects of it, as has been suggested by some correlational studies.

[gpapa]

I’m 66 plus. Can I get some money to study my brain please.

[onedoug]

Little is known about why this happens....

Because a younger brain is younger than an older one?

[sergeantdave]

I’d like for scientists to discover why when I throw 12 socks into the washing machine I only get 11 back. At this point in my life, sock loss is more important than memory loss.