To: All
The Role of Biomarkers in Clinical Trials for Alzheimer DiseaseMore recently, PET imaging studies using radioligands that bind directly to β-amyloid plaques have been performed.28,29 One of these ligands, Pittsburgh Compound-B (PIB), is a thioflavin derivative and appears to be relatively selective for β-amyloid plaques at the concentrations used for imaging studies. As shown in Figure 2, the binding of PIB to brain sections is highly correlated with total Aβ levels. Test/retest variability in clinical studies is less than 10% for most brain regions.30
15 posted on
12/06/2007 9:23:26 PM PST by
neverdem
(Call talk radio. We need a Constitutional Amendment for Congressional term limits. Let's Roll!)
To: neverdem
In laymens terms, they can’t work within the compound to destroy the plaque, thus the buildup of plaque disrupting the normal flow of impulses is continuous.
To: neverdem
More recently, PET imaging studies using radioligands that bind directly to β-amyloid plaques have been performed.28,29 One of these ligands, Pittsburgh Compound-B (PIB), is a thioflavin derivative and appears to be relatively selective for β-amyloid plaques at the concentrations used for imaging studies. As shown in Figure 2, the binding of PIB to brain sections is highly correlated with total Aβ levels. Test/retest variability in clinical studies is less than 10% for most brain regions.30 I have been saying that for years. Nobody listens.
47 posted on
12/06/2007 10:33:48 PM PST by
Mind-numbed Robot
(Not all that needs to be done, needs to be done by the government.)
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