The pinch is getting greater in many areas. You mentioned health care and that will be one. Small businesses have been feeling more and more of it for years. Gas prices play into that as well as into the price of consumable products. Illegal aliens also force small businesses into a Hobson's choice; hire illegals or cease to be competitive. For the employed worker they watch their wages fall or their jobs disappear altogether.
Being told to wear your seatbelt like a child and slapped around and insulted for smoking is just an irritant to most. When you find your choices in employment and health care reduced and degraded so far that you simply submit your family to what the government graciously offers or go without people are going to get very prickly. Add to it all greater identification requirements and more widespread data sharing, greater restrictions on self-defense, less effective LE and victim-hostile courts and the feeling of helplessness will become unbearable.
Anarchy has always been the natural response to tyranny. The question is whether it becomes organized and focused or devolves into a general lawless attitude where the populace just preys on itself and remains in a balance of tension as a vast underground vs the equally corrupt overworld of authority.
That's already happening, smokers being the original class of "prey" that the other classes have smugly attacked with government encouragement.
The next group is that defined by the government as "obese," though it appears that alchohol users are in the bull pen.
It's all going swimmingly for the Nanny Staters so far.
I predict the underground wins, at the cost of a government that's given up any pretense to representing a "free" society.
Amazing how fast it all happened once the ball got rolling.