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Most Science Studies Appear to Be Tainted By Sloppy Analysis
Wall Street Journal Online - Science Journal ^ | Sept. 14, 2007 | ROBERT LEE HOTZ

Posted on 09/14/2007 3:21:08 AM PDT by gridlock

We all make mistakes and, if you believe medical scholar John Ioannidis, scientists make more than their fair share. By his calculations, most published research findings are wrong.

Dr. Ioannidis is an epidemiologist who studies research methods at the University of Ioannina School of Medicine in Greece and Tufts University in Medford, Mass. In a series of influential analytical reports, he has documented how, in thousands of peer-reviewed research papers published every year, there may be so much less than meets the eye.

These flawed findings, for the most part, stem not from fraud or formal misconduct, but from more mundane misbehavior: miscalculation, poor study design or self-serving data analysis. "There is an increasing concern that in modern research, false findings may be the majority or even the vast majority of published research claims," Dr. Ioannidis said. "A new claim about a research finding is more likely to be false than true."

The hotter the field of research the more likely its published findings should be viewed skeptically, he determined.

(snip)

Statistically speaking, science suffers from an excess of significance. Overeager researchers often tinker too much with the statistical variables of their analysis to coax any meaningful insight from their data sets. "People are messing around with the data to find anything that seems significant, to show they have found something that is new and unusual," Dr. Ioannidis said.

(snip)

Every new fact discovered through experiment represents a foothold in the unknown. In a wilderness of knowledge, it can be difficult to distinguish error from fraud, sloppiness from deception, eagerness from greed or, increasingly, scientific conviction from partisan passion. As scientific findings become fodder for political policy wars over matters from stem-cell research to global warming, even trivial errors and corrections can have larger consequences.

(snip)

(Excerpt) Read more at online.wsj.com ...


TOPICS: Extended News; News/Current Events
KEYWORDS: globalwarming; globalwarmingisahoax; peerreview; research
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To: Tax-chick

In the mean time, an active mind is our best defense!


21 posted on 09/14/2007 5:14:35 AM PDT by gridlock (I do not support Hillary Clinton because I am afraid of strong women)
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To: gridlock

So it’s a good thing we’re here on FR, having lots of thoughts!


22 posted on 09/14/2007 5:33:39 AM PDT by Tax-chick ("My parrot thinks you're cute. I think so, too!")
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To: gotribe
Always follow the money.

Yup. With so much research being conducted within our universities the pressure to obtain grant money has never been greater. As the article makes clear, too many researchers are more interested in finding money than they are with finding the truth. This causes them to do things that guarantee the desired outcome and place their findings under suspicion. 95% of research today is meaningless.

No organization is more guilty of this than the Center for Science in the Public Interest.

23 posted on 09/14/2007 6:07:59 AM PDT by Mase (Save me from the people who would save me from myself!)
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To: angkor
My favorite and most recent “refereed scientific study” claimed that pregnant women should avoid sushi, because fish contains relatively high levels of mercury and other toxic substances.

The multiple absurd flaws here are self-evident, so I’ll just mention this one: does the mercury go away when raw sushi is cooked?

Why is this not logical?

There is no logical flaw where the scientists say that sushi might be harmful. The statement could be generalized, but that doesn't make it wrong.

For example, I could say that a .40 S&W cartridge can cause harm if you use it in a gun to shoot at yourself. I could generalize it more (to include other bullets), but it isn't wrong as is.

24 posted on 09/14/2007 6:13:24 AM PDT by burzum (None shall see me, though my battlecry may give me away -Minsc)
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To: Mase
No organization is more guilty of this than the Center for Science in the Public Interest.

Those idiots don't even bother to fake it.

25 posted on 09/14/2007 6:20:32 AM PDT by gridlock (I do not support Hillary Clinton because I am afraid of strong women)
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To: gridlock
I suspect a lot of these ‘scientists’ start with a belief about what they want to demonstrate in the study.

The study itself is devised primarily to meet mere standards for review — the analysis is easy since they knew going in what their conclusions would be.

26 posted on 09/14/2007 7:32:51 AM PDT by BenLurkin
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To: BenLurkin

It used to be the assumption was that scientists were committed to the scientific process first and their own agendas second. This has not been true for a long, long time.


27 posted on 09/14/2007 7:45:24 AM PDT by gridlock (I do not support Hillary Clinton because I am afraid of strong women)
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To: burzum
For example, I could say that a .40 S&W cartridge can cause harm if you use it in a gun to shoot at yourself. I could generalize it more (to include other bullets), but it isn't wrong as is.

Sorry, that's not the correct formulation.

The equivalent might be "Pregnant women should not drive Harley Davidsons, because motorcycles have high injury rates in accidents. I have therefore proven that Harley Davidsons are dangerous for pregnant women."

That's at least a double non sequiter, and one or two other logical fallacies.

I have to run but can take this up later if you like.

28 posted on 09/14/2007 8:29:57 AM PDT by angkor ("Everyone is super stoked on me, even if they don't know it." - Al Gore, South Park 10.6)
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To: angkor
I have to run but can take this up later if you like.

Nah. It isn't really important. And talking about .40 S&W makes me want to go to the range.

29 posted on 09/14/2007 8:33:55 AM PDT by burzum (None shall see me, though my battlecry may give me away -Minsc)
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To: gridlock

Statistics is not science and it is not history or sociology although it seems to be used extensively and blindly in those disciplines. Statistics provide an answer that is implied in the question so the mere phrasing of the question determines the result. We ought to pay more attention to the questions and less or none to the results.


30 posted on 09/14/2007 8:38:32 AM PDT by RightWhale (Snow above 2000')
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To: gridlock

Too often one treats the hypothesis more as a road map than a set of landmarks already located and assumes that the road ends there.


31 posted on 09/14/2007 8:59:13 AM PDT by Old Professer (The critic writes with rapier pen, dips it twice, and writes again.)
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To: gridlock

Have you ever read the study of the taint in a medical journal?


32 posted on 09/14/2007 9:00:43 AM PDT by Old Professer (The critic writes with rapier pen, dips it twice, and writes again.)
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To: gridlock
Here's a PDF of the article mentioned in the piece: Why Most Published Research Findings Are False
33 posted on 09/14/2007 10:25:49 AM PDT by John Jorsett (scam never sleeps)
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To: gridlock

thanks, bfl


34 posted on 09/14/2007 2:14:28 PM PDT by neverdem (Call talk radio. We need a Constitutional Amendment for Congressional term limits. Let's Roll!)
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To: gridlock

Science ceased to be science when it became political activism.

Now it is all tainted.


35 posted on 09/14/2007 2:36:36 PM PDT by TASMANIANRED (TAZ:Untamed, Unpredictable, Uninhibited.)
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To: Tax-chick

TC, the companies that I follow are very tight-lipped, but some powerful anecdotal info have nonetheless leaked out. If true, and I believe they are, we could see a mega breakthrough on the market in as soon as one year.

GB,
p.


36 posted on 09/14/2007 3:43:48 PM PDT by Paul_B
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To: gridlock

Any really astute professor, in ANY field, should make this announcement at the beginning of the year, every year, with every incoming cohort of students:

“At least 50% or what we teach you in this classroom, as settled and highly researched fact, will prove to completely and totally WRONG, sometime during your career. We cannot tell you which 50% that is. You have to learn that for yourselves.”

The piece of data you KNOW is absolutely right, and completely irrefutable, will turn out to be total bull puckie. And it will be proven to be so by some young grad student who is not yet born.


37 posted on 09/14/2007 3:46:28 PM PDT by alloysteel (Never attribute to ignorance that which is adequately explained by stupidity.)
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To: gridlock
There’s a difference between sloppy and intentionally careless to appease someone providing grants and/or funds.

“The Great Betrayal,” by Horace Freeland Judson.

38 posted on 09/14/2007 3:52:53 PM PDT by Ghost of Philip Marlowe (Liberals are blind. They are the dupes of Leftists who know exactly what they're doing.)
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To: Paul_B

Amazing! I hope there’s something that can help my father, before it’s too late.


39 posted on 09/14/2007 3:58:22 PM PDT by Tax-chick ("My parrot thinks you're cute. I think so, too!")
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To: gridlock
Given the epidemic of junk science after WWII, this really isn’t very surprising.
40 posted on 09/14/2007 4:00:16 PM PDT by colorado tanker (I'm unmoderated - just ask Bill O'Reilly)
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