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Hostility, anger linked to chronic inflammation
Reuters via Yahoo! ^ | 8-2-07 | Anne Harding

Posted on 08/02/2007 6:32:50 PM PDT by Dysart

NEW YORK (Reuters Health) - Men with high levels of hostility, anger and depression show increases in a key marker of inflammation over time, which may put them at greater risk of heart disease, a new study shows.

"This is further data suggesting that this stuff is bad for your health," Dr. Stephen H. Boyle of Duke University Medical Center in Durham, North Carolina, the study's lead author, told Reuters Health. "It's not good to have high levels of hostility, anger and depression."

Such psychological factors have long been linked to heart disease, but the mechanism through which they harm the heart and blood vessels has not been established, Boyle and his colleagues note in the current issue of Brain, Behavior and Immunity. However, they add, there is mounting evidence that these emotions may contribute to inflammation in the body.

To investigate, Boyle and his team looked at levels of two inflammation markers, C3 and C4, in 313 men, who were an average of 50 years old, participating in the Air Force Health Study, a long-term investigation of the effects of Agent Orange. They assessed the men's level of hostility, anger and depression in 1985 and measured their C3 and C4 levels in 1992, 1997 and 2002.

Men with the highest levels of anger, depression and hostility also showed the greatest increase in C3 levels between 1992 and 2002, the researchers found. But there was no association between these psychological factors and levels of

C4.

Research has linked higher levels of C3 to a greater risk of heart disease, abnormal heart rhythms and diabetes, Boyle and his team point out. They believe these findings provide additional support to the hypothesis that emotional factors contribute to health problems by influencing levels of chronic inflammation.

In an interview, Boyle pointed out that the assessment for hostility, anger and depression took place seven years before measurements of C3 and C4 began, and that all study participants were "very, very healthy," making it unlikely that, for example, the men might be depressed because of some underlying health problem that could also boost C3 levels. "That gives us a lot of confidence that these psychological factors precede the increase in inflammation."

While most people who are depressed will want to get treatment, Boyle noted, many individuals with hostile personalities may not be aware of it, and are thus unlikely to seek help.

However, there are definitely ways to lessen the impact of personality on health, he added. For example, he said, stress reduction techniques are helpful. "Even if you get angry, the consequences may be less severe if you're able to calm down quicker or if you're able to develop techniques to become angry less easily."

SOURCE: Brain, Behavior and Immunity, August 2007.


TOPICS: Miscellaneous
KEYWORDS: c3; c4; hostility; inflammation
Relax.
1 posted on 08/02/2007 6:32:56 PM PDT by Dysart
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To: Dysart
My constant inflammation makes me hostile and angry.
2 posted on 08/02/2007 6:34:51 PM PDT by elizabetty (The funding dried up and I can no longer afford Tagline Messages.)
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To: Dysart

So, if the Kos Kiddies keep getting all roused up, they’ll fill up with C4 and their heads might really explode?


3 posted on 08/02/2007 6:35:29 PM PDT by Grimmy (equivocation is but the first step along the road to capitulation)
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To: Dysart

Kind of a “No Chit Chirlock” study...


4 posted on 08/02/2007 6:37:07 PM PDT by xcamel ("It's Talk Thompson Time!" >> irc://irc.freenode.net/fredthompson)
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To: Dysart

High levels of C4 in the bloodstream get me so worked up I want to explode


5 posted on 08/02/2007 6:37:41 PM PDT by mylife (The Roar Of The Masses Could Be Farts)
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To: mylife; y'all
Yes, I understand...FYI, here's more on C3-C4:

C3 and C4 complement

C3 and C4 complement are parts of a group of globulin proteins found in the blood. Globulins carry substances through the bloodstream. C3 and C4 complement help the body's immune system react to inflammation and infection.

The results of the blood test for C3 and C4 complement help monitor the condition of people with kidney disease (nephritis) or lupus. The results can also help diagnose angioedema, an allergic reaction.

6 posted on 08/02/2007 6:41:20 PM PDT by Dysart
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To: xcamel
Kind of a “No Chit Chirlock” study..

Yeah, but the mechanism here is what's interesting. At least to me.

The association between stress/hostility and cardio disease has been clear for some time, of course.

7 posted on 08/02/2007 6:46:42 PM PDT by Dysart
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To: Dysart
At fisrt glance I mis-read the title as:

Hillary, anger linked to chronic inflammation

and I thought to myself, "ah, that would explain quite a bit..."
8 posted on 08/02/2007 6:57:10 PM PDT by zadox
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To: Dysart

Soma.

Prescribed by government medicos. Given to anyone who looks like they might be angry with how many liberties they have lost and continue to lose.

There’s even a catchy slogan to go with the program.

“Better a gram than a damn.”


9 posted on 08/02/2007 7:31:45 PM PDT by BenLurkin
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To: Dysart
Tomorrow's headline today:

Inflammation Nation Explanation


10 posted on 08/02/2007 7:35:47 PM PDT by Revolting cat! (We all need someone we can bleed on...)
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To: Dysart

So that’s it. I thought it was the Y chromosome.


11 posted on 08/02/2007 7:41:21 PM PDT by tennteacher (Duncan Hunter '08)
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To: Dysart

Bite me you )%$$#@8b fool of a(*&*&%# and your $%@*&%# too


12 posted on 08/02/2007 7:43:29 PM PDT by Drango (A liberal's compassion is limited only by the size of someone else's wallet.)
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To: BenLurkin

13 posted on 08/02/2007 7:43:50 PM PDT by Dysart
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To: Drango
Bite me you )%$$#@8b fool of a(*&*&%# and your $%@*&%# too

You can call me out anytime, but dontcha talk 'bout mah $%@*&%#!

14 posted on 08/02/2007 7:47:53 PM PDT by Dysart
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To: Dysart
My paternal grandfather was the angriest man I ever met.

He lived to see his 106th birthday.

These bozos used to tell us, "don't suppress your feelings, it wrecks your health." Now the same nitwits are telling us, "don't express your feelings, it wrecks your health."

Remember all that talk about "type A personalities" and heart disease back in the 60s and 70s? That turned out to be a total crock too.

I think I'll just live my life the way I want.

15 posted on 08/02/2007 8:53:55 PM PDT by Bonaparte
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To: Dysart
Men with high levels of hostility, anger and depression show increases in a key marker of inflammation over time, which may put them at greater risk of heart disease, a new study shows.

This is another study confusing correlation and causation. It's know that spirochetes cause dramatic neurological effects, and chronic Lyme is rampant in this country. The neurological effects mentioned here might just be leading symptoms of the disease, not the causative factor.

try searching for 'Lyme Rage'.

16 posted on 08/02/2007 10:04:01 PM PDT by slowhandluke (It's hard work to be cynical enough in this age)
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