I prefer Rugers, but that may just be me... I've never really been comfortable with Glocks, something about them just doesn't rub me right.
Nah, it's not just you. I'm a righty, but my wife shoots left handed so it's handy to have a thumb safety on both sides like a Ruger. Her only gripe is that the slide release is oriented for righties. Plus I have relatively small hands, so Glock and Sig grips aren't comfortable to me.