Posted on 01/10/2007 10:42:50 PM PST by neverdem
Women can take the anti-AIDS drug nevirapine to protect their unborn children without endangering their ability to undergo life-saving antiretroviral treatment later on, a new study has found.
The results are good news for poor women in Africa, Asia and Latin America who must take nevirapine, an inexpensive first-line drug that often prevents the transmission of H.I.V. from mother to child.
The drug lingers in the blood up to three weeks, and if the mother has the virus that causes AIDS, its presence encourages the growth of nevirapine-resistant strains. That has led to fears that any antiretroviral drug cocktail containing nevirapine would be useless.
But the new study, published today in The New England Journal of Medicine, finds that such a cocktail is still effective if women simply delay it for six months after taking the protective dose of nevirapine.
The study was done by Harvard researchers working in Botswana but has implications for poor women everywhere. Early reports of data gathered in the study, along with evidence from similar ones, influenced the World Health Organization’s new AIDS treatment guidelines last year, helping to keep nevirapine in the arsenal of first-line AIDS drugs.
“This is a real glimmer of hope,” said Dr. Catherine Hankins, chief scientific adviser for Unaids, the United Nations AIDS agency. “There was real concern that single-dose nevirapine was blowing the use of that whole class of drugs.”
Nevirapine has never been a perfect drug; in prolonged use, it can poison the liver and cause rashes, and the virus that causes AIDS only needs to make a single mutation to develop resistance to it.
In wealthy countries, women are usually given a short course of two or three antiretroviral drugs late in the pregnancy to prevent passing the virus to their babies, and birth infections are now...
(Excerpt) Read more at nytimes.com ...
Good news. I hope they spread the drug throughout Africa.
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