[muawiyah]

If you are using glucophage also known as metformin, one of the warnings is to NOT take Avandia at the same time, or even in rapid succession with glucophage upon starting Avandia.

The reason is you will most likely get a heart attack.

You have to stop the one, wait some period of time, and start the other.

I'd say your physician could advise you how long that might be and there doesn't seem to be any information on the net concerning the matter.

So, it's not just a potential "side effect" ~ you can induce a heart attack simply switching from one drug to the other.

[PCBMan]

Huh? Those two are combined in one medicine, Avandamet. I've been taking it for 2 years now. Nobody mentioned anything about heart attacks, and I haven't had any problems. It has helped tremendously.

[Alex Murphy]

If you are using glucophage also known as metformin, one of the warnings is to NOT take Avandia at the same time, or even in rapid succession with glucophage upon starting Avandia.

The reason is you will most likely get a heart attack.

Ouch!

[neverdem]

I'd say your physician could advise you how long that might be and there doesn't seem to be any information on the net concerning the matter.

So, it's not just a potential "side effect" ~ you can induce a heart attack simply switching from one drug to the other.

I am a physician. I'd say your friend had underlying coronary artery disease and bad luck if he had a myocardial infarction. The timing was an untimely co-incidence.

If he had an episode of congestive heart failure, which is not the same diagnosis, that was probably due to just the Avandia. Avandia interacts with a number of other drugs, but the only adverse effect that I would expect the combination of Avandia and metformin is hypoglycemia. I would be wary of what I find on the internet. I just scanned rosiglitazone and metformin, adverse effects on PubMed. You're welcome to see what I missed.

[zarf]

Maybe if the fat, fat fatties would quick drinking sodas by the lake full and quit eating sugary snacks it may alleviate the need for drugs.

Exercise....carrots instead of Butterfingers?

[jammer]

...and there doesn't seem to be any information on the net concerning the matter.

That's interesting. Maybe because it isn't true?

My Cerner-Multum Clinical Database shows no major or moderate interaction between metformin and rosiglitazone. In fact, in the rosiglitazone monograph, they say:

"Rosiglitazone is indicated as monotherapy. The drug is also indicated for use in combination with a sulfonylurea or metformin when diet, exercise, and rosiglitazone alone or diet, exercise and the single agent do not result in adequate glycemic control. For patients inadequately controlled with a maximum dose of a sulfonylurea or metformin, rosiglitazone should be added to, rather than substituted for, a sulfonylurea or metformin." [Emphasis mine]