Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Evolution reversed in mice
BBC Online ^ | Aug 7, 2006

Posted on 08/07/2006 2:13:03 PM PDT by Lt_funk

Evolution reversed in mice

The mouse looks the same but has an ancient gene US researchers have taken a mouse back in time some 500 million years by reversing the process of evolution.

By engineering its genetic blueprint, they have rebuilt a gene that was present in primitive animals.

The ancient gene later mutated and split, giving rise to a pair of genes that play a key role in brain development in modern mammals.

The scientists say the experiments shed light on how evolution works and could lead to new gene therapy techniques.

"We are first to reconstruct an ancient gene," said co-researcher Petr Tvrdik of the University of Utah. "We have proven that from two specialised modern genes, we can reconstruct the ancient gene they split off from.

"It illuminates the mechanisms and processes that evolution uses, and tells us more about how Mother Nature engineers life."

Brain development

The study, published in the academic journal Developmental Cell, involved a suite of genes involved in embryonic development.

It gives a real example of how evolution works because we can reverse it Prof Mario Capecchi

Until about 500 million years ago, early animals had 13 such Hox genes. Then each gene split into four, making 52 genes.

Over the course of evolution, further mutations occurred, and some genes became redundant and disappeared, leading to today's tally in mammals of 39 Hox genes.

The Utah team looked at two of these genes; Hoxa1, which controls embryonic brain development, and Hoxb1, which plays a key role in the development of nerve cells that control facial expressions in animals.

Hybrid gene

The Utah pair combined critical sections of each gene, reconstructing a gene similar to its equivalent some 530 million years ago.

The hybrid gene is not completely identical to the ancient one, but the scientists say it performs essentially the same functions.

"What we have done is essentially go back in time to when Hox1 did what Hoxa1 and Hoxb1 do today," said Mario Capecchi, professor of human genetics at the University of Utah School of Medicine.

"It gives a real example of how evolution works because we can reverse it."


TOPICS: News/Current Events
KEYWORDS: bewareofluddites; evolution; goddooditamen
Navigation: use the links below to view more comments.
first 1-2021-35 next last
Pretty interesting stuff
1 posted on 08/07/2006 2:13:03 PM PDT by Lt_funk
[ Post Reply | Private Reply | View Replies]

To: Lt_funk; PatrickHenry

thought you'd be interested in this


2 posted on 08/07/2006 2:13:59 PM PDT by Lt_funk
[ Post Reply | Private Reply | To 1 | View Replies]

To: Lt_funk

Reversed evolution? You mean, they cloned a lib?


3 posted on 08/07/2006 2:14:13 PM PDT by JamesP81 ("Never let your schooling interfere with your education" --Mark Twain)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Lt_funk

Wow, way cool, thanks.


4 posted on 08/07/2006 2:15:08 PM PDT by LibWhacker
[ Post Reply | Private Reply | To 1 | View Replies]

To: Lt_funk
The mouse looks the same but has an ancient gene US researchers have taken a mouse back in time some 500 million years by reversing the process of evolution.

So they turned a mouse into a fish? There were NO mammals around half a billion years ago.

5 posted on 08/07/2006 2:16:15 PM PDT by Centurion2000 (Islam is a subsingularity memetic perversion : (http://www.orionsarm.com/topics/perversities.html))
[ Post Reply | Private Reply | To 1 | View Replies]

To: Lt_funk

Well, since scientists did it, doesn't that make it intelligent design?


6 posted on 08/07/2006 2:17:05 PM PDT by Grig
[ Post Reply | Private Reply | To 1 | View Replies]

To: Lt_funk

Naaaah... Don't believe it.
7 posted on 08/07/2006 2:18:29 PM PDT by dangus
[ Post Reply | Private Reply | To 2 | View Replies]

To: Grig
Well, since scientists did it, doesn't that make it intelligent design?

Oh, you did it now...
8 posted on 08/07/2006 2:18:49 PM PDT by Thrusher ("...there is no peace without victory.")
[ Post Reply | Private Reply | To 6 | View Replies]

To: dangus

"Oh no! I've accidentally reversed the device! I've turned him into a Neanderthal Rabbit!"


9 posted on 08/07/2006 2:20:11 PM PDT by sinanju
[ Post Reply | Private Reply | To 7 | View Replies]

To: Centurion2000
Until about 500 million years ago, early animals had 13 such Hox genes You're right, it was passed down from non-mammalian animals.
10 posted on 08/07/2006 2:20:22 PM PDT by Lt_funk
[ Post Reply | Private Reply | To 5 | View Replies]

To: Lt_funk
How about some retroactive birth control for Al Franken?

Image Hosted by ImageShack.us

11 posted on 08/07/2006 2:20:59 PM PDT by jdm (Another day, another Helen Thomas pic)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Lt_funk

No - No I Say!....no Helen Thomas stuff!!!


12 posted on 08/07/2006 2:21:11 PM PDT by patriot_wes (Law of Unintended Consequences; Infant Baptism = an unbelieving, unsaved church.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Lt_funk
We've been told by a few Darwiniacs that there is no such thing as "reverse evolution."

we'll give you a little time to get those retractions in,,,,if you need a few million extra years to get it together, we can be accomodating.

13 posted on 08/07/2006 2:23:30 PM PDT by cookcounty (Army Vet, Army Dad)
[ Post Reply | Private Reply | To 1 | View Replies]

To: cookcounty

Please elaborate - I'm not sure to what you're refering.


14 posted on 08/07/2006 2:24:19 PM PDT by Lt_funk
[ Post Reply | Private Reply | To 13 | View Replies]

To: Lt_funk

It split into smart, and not smart.

It split into relegeon, and non-religeion.

Ooops. Redundant.


15 posted on 08/07/2006 2:24:38 PM PDT by MonroeDNA (I've got a possum in my pants.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: patriot_wes
No - No I Say!....no Helen Thomas stuff!!!

Sorry, cannot get out of 'obligation via tagline.' Besides, I don't think I've posted a Helen Thomas pic today yet. Oh wait, yeah, I did. Oh well, another never hurts! :O)


16 posted on 08/07/2006 2:24:47 PM PDT by jdm (Another day, another Helen Thomas pic)
[ Post Reply | Private Reply | To 12 | View Replies]

To: cookcounty

If you start a debate with invective, don't expect it to be civil.


17 posted on 08/07/2006 2:27:15 PM PDT by stands2reason (ANAGRAM for the day: Socialist twaddle == Tact is disallowed)
[ Post Reply | Private Reply | To 13 | View Replies]

To: MonroeDNA

Huh? What are you on about?


18 posted on 08/07/2006 2:27:52 PM PDT by stands2reason (ANAGRAM for the day: Socialist twaddle == Tact is disallowed)
[ Post Reply | Private Reply | To 15 | View Replies]

To: Lt_funk

Reversal of evolution certainly doesn't fit the popular idea of progress.


19 posted on 08/07/2006 2:28:39 PM PDT by RightWhale (Repeal the law of the excluded middle)
[ Post Reply | Private Reply | To 1 | View Replies]

To: cookcounty
"We've been told by a few Darwiniacs that there is no such thing as "reverse evolution.""

Can you site a source, or are you the GHG?

20 posted on 08/07/2006 2:29:16 PM PDT by MonroeDNA (I've got a possum in my pants.)
[ Post Reply | Private Reply | To 13 | View Replies]


Navigation: use the links below to view more comments.
first 1-2021-35 next last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson