You have to list on your security clearance forms all relatives who not US citizens and all relatives by marriage who not US citizens. Also if you do business overseas or hold a foreign passport.
Once you obtain your clearance, you are now required to fill out a foreign contact report if have anything to do with a foreign national.
When I lived in DC, I filled out at least one foreign contact report a week from cabbies, waiters, etc.
I know someone whose father's security clearance got extra scrutiny because his last name was spelled the same as a leading figure in the American Communist Party...in effect, he had to prove that they were not related. (In fact, the names originated in different countries but just happened to be spelled alike.)