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You of course have to check your state constitution to find out if the powers to regulate driving, practice of medicine, and marriage are given to the state by the people. None are regulated at the federal level.

The fact that at one time something was not regulated does not mean it cannot or should not be regulated by the government.
Driving became possible before people realized how potentially dangerous an act it was. So the laws had to catch up later.
Drivers' licenses mean that the government has attempted to ascertain that you are competent to be driving a ton or so of metal down the road at 20-65 miles per hour. You of course might be perfectly capable of driving safely. How about that nimrod coming towards you at 45 mph just on the other side of the double line? Do you want someone to at least have checked out whether that clod has any clue what he is doing?
At the start of the Republic basically all doctors were quacks. His doctor bled George Washington just before he died. On some quack theory or another.
As late as the Civil War doctors had no idea of the proper sanitary practices for amputations in order to minimize post surgery infections.
If you point out that licenses do not prevent all the potential catastrophes, that is true. But everyone believes that they do help reduce the number of incompetent people doing potentially danger things.
If you have a better idea, run for office, put your better idea in place.

"The fact that at one time something was not regulated does not mean it cannot or should not be regulated by the government".

That may or may not be true. Something that wasn't regulated indicates that the government either didn't have the power to regulate it or never used said power. Just because you or I (or the president or congress or the USSC) think that something should be regulated does not give the government any additional powers. Government is limited to those powers that they are given by constitutional enumeration. If enough people feel that government should have an additional power then the constitution should be amended to cede that power to government. It's rather immaterial to mention the good reasons why government should have a power as without the constitutional process we no longer have a government of limited powers.

"If you have a better idea, run for office, put your better idea in place."

The constitution is already in place. All I'm asking is that it be obeyed.