Posted on 03/14/2006 11:14:41 AM PST by S0122017
He, concerning the supposed poisoning of Milosevic by rifampicine:
There happens to be a doctor at my (dutch) university that dod research to the mechanism behind the compound. He concluded the following:
1) Every doctor worth their money can understand that the substance increased drug breakdown by the liver and thus renders medicines ineffective, it has been known for 30 years
2) Poisoning is unlikely due to the huge amounts of the substance required
3) Rifampicine colours youre urine orange strongly, which should have been noticable by Milosevic and any doctor checking urine samples
4) He suggest that maybe Milosevic poisoned himself to convince doctors to let him go to Russia.
I don't buy his final conclusion myself, Milosevic DID mention that he was in danger of being poisoned, doesn't sound like you would mention if you where poisoning yourself. Yet, it colours you're urine orange! How he mis THAT?!
I didnt ment for it to get posted twice.
Plz refer to http://www.freerepublic.com/focus/f-news/1596108/posts
Wikipedia
Indications
It is typically used to treat Mycobacterium infections, including tuberculosis and leprosy; and also has a role in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in combination with fusidic acid. It is also used in prophylactic therapy against Neisseria meningitidis (meningococcal) infection.
It is also used to treat Staphylococcus aureus (MRSA in particular), Listeria species, Neisseria gonorrhoeae, Haemophilus influenzae and Legionella pneumophila For these non-standard indications, sensitivity testing should be done (if possible) before starting rifampicin therapy. Rifampicin resistance develops quickly during treatment and rifampicin monotherapy should not be used to treat these infections – it should be used in combination with other antibiotics.
Enterobacteriaceae, Acinetobacter and Pseudomonas species are intrinsically resistant to rifampicin.
Mechanism of action
Rifampicin inhibits DNA-dependent RNA polymerase in bacterial cells by binding its beta subunit, thus preventing transcription of messenger RNA (mRNA) and subsequent translation to proteins.
Adverse effects
Adverse effects are chiefly related to the drug's hepatotoxicity, and patients receiving rifampicin often undergo liver function tests including aspartate aminotransferase (AST).
The most common unwanted effects are fever, gastrointestinal disturbances, skin rashes and immunological reactions. Liver damage, associated with jaundice, has also been reported and in some rare cases has lead to death.
Taking rifampicin can cause certain bodily fluids, such as tears and semen, to be become orange-red in color. This may permanently stain soft contact lenses. It also may be excreted in breast milk, therefore breast feeding should be avoided.
Rifampicin is an inducer of hepatic cytochrome P450 enzymes (such as CYP2D6 and CYP3A4) and will increase the metabolism of a many drugs that are cleared by the liver through this enzyme system. This results in numerous drug interactions such as reduced efficacy of the oral contraceptive pill.
Retrieved from "http://en.wikipedia.org/wiki/Rifampicin"
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.