Just to hilight the point of subdiscussion here ... You seem to have put forth an assertion that Shapiro's claim that he has observed high rates of surviving mutants in single celled organisms discounts Schwartz's claim that cells STRONGLY resist mutation. Do I have that correct?
Nope. They both claim (I believe correctly so) that cells strongly resist mutation. Shapiro (and now apparently Schwartz) claim that the mutations are in response to external stimuli and are not just accidental.