You double odds of hitting a pedestrian since they can't hear you coming. If you drive a hybrid in the city, you might never run a yellow light and be super vigilant. And buy lawsuit insurance so the ambulance chasers don't totally clean you out.
I don't why you'd have to be any more vigilant than you'd normally be. If the pedestrian is in the street while you're driving, you should see him anyway. I'm sure hybrid cars still have horns, right?