.45ACP was the first cartridge I started reloading. My Springfield 1911 was getting pricey to feed. I built my initial brass reserve shooting CCI ammo. That brass is very good for reloading. As time went on, I couldn't always get all my own brass back at the range. I also found a bunch of other headstamps that yielded unpleasant results. I paid my kids to sort the brass and removed the difficult stuff from the reserve for reloading.
I've considered re-loading .50 BMG, but with the availability of ammo, it doesn't seem like it would be cost effective.
There's lots of good plinking grade surplus available. When you get ready to reload, you'll probably have to get a dedicated press that is a bit longer internally than the average press used for handgun rounds. Unless you are doing really long range precision shooting, it is probably not a big advantage to reload.
L