Are there states where the reverse is true? (Having to run as a strong social conservative, but maintain a fiscally moderate or even liberal platform)
Just off the top of my head, I don't think so. Some of the red states that are embracing "compassionate conservatism", like Texas, may go that way in the future though.
It's ironic that a fiscal conservative/social libertarian is probably the most winnable position but a candidate with those stances has an almost impossible time making through the primaries of either party.