Is there a possibility that you could ride out the storm at your wife's hospital? If some of the staff evacuated, could they use volunteer help for some of the simple tasks? Keeping busy helps the time past faster. If IIUC, you aren't in the storm surge area and aren't along a bayou or in a flood zone area, yes?
Maps to doublecheck:
http://www.houstontx.gov/oem/c5ss.jpg
http://www.srh.noaa.gov/hgx/tropical/evac_map/gifs/
While I certainly don't want to encourage anyone who can evacuate to stay behind, for the essential personnel and their families who must stay keep in mind that even during the 1900 storm in Galveston, where we see the images of miles of debris wiped out by storm surge, more than 80% of the city's population SURVIVED even all that.
Also, the trend is still eastward. 6Z models were spread from a center of Galveston west to Matagorda and east to the LA border. 12Z models continue this eastward movement, spread from Galveston to Lake Charles, with an increasing cluster east of High Island.
http://euler.atmos.colostate.edu/~vigh/guidance/atlantic/early1.png
Can still move either way, but the odds of the worst case are still low. Not sugarcoating, but keeping perspective. Don't get too discouraged, still a long way to go with this.
Yes, that is my current plan. Only if the storm track continues to shift east will I consider staying. I don't have to make that decision until probably noon tomorrow.