With one small genetic adjustment in Influenza A, or H5N1, millions of people could die, warned World Health Organization Regional Director for the Western Pacific Shigeru Omi. Posted on 09/20/2005 12:51:10 AM PDT by M. Espinola
A recently evolved avian flu virus could mutate and become transmissible between humans, touching off a massive global pandemic, agreed public health officials from more than 20 countries in the Western Pacific region who gathered yesterday.
With one small genetic adjustment in Influenza A, or H5N1, millions of people could die, warned World Health Organization Regional Director for the Western Pacific Shigeru Omi.
Omi, speaking at the regional WHO meeting in Noumea, New Caledonia, in the South Pacific, called for health ministers and representatives to launch an all-out war on the deadly strain, which has killed at least 57 people.
"While we still have a window of opportunity, we must do everything we can to avert an influenza pandemic as we simultaneously prepare for a worse-case scenario," Omi said in his address.
If the virus acquires sufficient human genes, allowing transmission from one person to another, an estimated 2 million to 7.4 million people around the world could die, the WHO estimates.
Others put the figure in the tens of millions.
In Jakarta yesterday, authorities closed down the popular Ragunan Zoo and had workers tested after rare eagles, peacocks and other birds were infected by the virus.
Three children suspected of contracting the disease were being treated at the Indonesian capital's infectious diseases hospital. Two of the children are in serious condition.
Nine days ago, a 37-year-old woman became the fourth fatality in Indonesia, where the virus has become endemic in chicken flocks across island nation.
According to the WHO, the Ministry of Health in Vietnam confirmed an additional fatal case of H5N1 infection that dates back to July, a 35-year-old male farmer from Ben Tre Province.
Since mid-December, 21 have died in Vietnam in 64 cases.
Worst case
The worst-case scenario, the New York Times reported, would be if person-to-person transmission spawned successive generations of severe disease with high mortality – the situation during the great influenza pandemic of 1918-1919, which killed an estimated 40 to 50 million people.
The early 20th century disaster resulted from the emergence of a completely new influenza virus subtype that spread worldwide in four to six months, causing several waves of infection over two years.
The H5N1 virus, which spreads through migratory birds, has plagued poultry populations in Asia since 2003, exposing more humans.
More than 140 million birds have died, and half of the 112 people infected have succumbed to the virus.
Russia is the most recent of 10 countries where the virus has turned up, and it now is threatening Europe, according to WHO officials.
The U.S. Centers for Disease Control says the world's defenses against flu are improving but remain inadequate, the Financial Times reports.
There is no pre-existing human immunity to the H5N1 virus.
"We've never seen so much influenza in so many birds in such close proximity to humans in so many places," said CDC Director Julie Gerberding. "If ever there was a time when the risk [of a pandemic] was higher than usual it is now."
At the United Nations last week, President Bush proposed an "international partnership" to combat the disease, requiring members facing an outbreak to share information immediately.
Already Vietnam, Japan, Cambodia, Thailand, Nigeria and Canada have indicated interest in the partnership.
"We cannot afford to face the pandemic unprepared," WHO Director Lee Jong Wook said Thursday at the United Nations.
To shore up its drug stockpile, the U.S. has awarded more than $100 million to two European pharmaceuticals, France's Sanofi pasteur of Sanofi-Aventis and Britain's GlaxoSmithKline.
"These countermeasures provide us with tools that we have never had prior to previous influenza pandemics," said Mike Leavitt, secretary of Health and Human Services, last week.
But WHO officials acknowledge that because the new virus has not changed in a way that would enable human-to-human transmission, they don't know precisely how they would combat it.
"We know we're overdue for an influenza pandemic strain, and we know it will occur, but we don't know when or even exactly what virus will cause it," Dick Thompson, a WHO spokesman, told the New York Times. "It is possible that the virus won't be H5N1 at all or that this virus will change in a way so that the vaccine under development doesn't work against it."
Gerberding, according to the Financial Times, agreed the laws of probability suggest a pandemic is due, noting the world has gone an unusual number of years since the last one in 1968, when the Hong Kong flu killed an estimated 1 million people.
The CDC director said the pharmaceuticals industry had the capacity to produce about 900 million doses of human vaccine against bird flu within several months.
But she pointed out this would meet only a fraction of the need in the event of a pandemic.
Word of caution
Some observers are urging caution amid growing discussion of "doomsday scenarios."
Bill Mattos, president of the California Poultry Federation, writing in the Modesto Bee, acknowledged the virus is a serious disease for bird species capable of causing illness and death in humans.
But he noted the virus has not been detected in North America despite its presence in Asia since 1996.
While some scientists suggest migratory birds will carry the virus overseas, the Asian flocks that travel to the western fringes of the Alaskan coast have shown no indication of the virus in the 12,000 samples taken by University of Alaska researchers from 1998-2004. These birds do not fly into the lower 48 states, Mattos pointed out.
For a pandemic to emerge, a human must simultaneously be infected with human influenza and avian influenza, Mattos argued.
"Subsequently, the two viruses must then meet in the same cell and genetically reassemble to create a unique 'avian-human' influenza virus," a mutation that has occurred only three times in recorded history.
He also points out that the confined, environmentally controlled housing of U.S. poultry flocks prevents contact between infected wild waterfowl and commercial poultry – a barrier rarely employed in Asia.
graphics added
WHO director says not much we can do anyway because vaccine developed ahead of the actual mutation might be useless, and once/if a flu hits it takes too long to ramp up and develop a vaccine specific to the mutated flu.
http://www.breitbart.com/news/2005/09/20/MTFH19822_2005-09-20_05-56-51_SCH016489.html
Note to self: Stop picking yer nose.
This is no drill!
Other updates:
Malaysia on bird flu alert, poultry shares down
US talks on Roche flu drug deal continue
Continue? This situation should have been resolved at least four years ago with Roche or other drug makers. Who, or whom has been sleeping at the switch again?
Well, once again it looks like we should forget about counting on the government for assistance this flu season. Incredible!
Roche stock was up (Monday) 1.1 percent at 184.50 Swiss francs at 0934 GMT.
He went on to say that I should continue to wash my punkies before I eat my din-din, take a bath daily, don't go mating with birdies and I'll be all right.
I'll listen to my cockatiel.
On second thought...
It's THE STAND come to life
Crow and all..
Stephen King is a prophet!!!
Wow dude! Thanks for the heads up dude.
Reminded me that I must go out in the dark, dude, and drain the chlorine from my well and house taps. You see I am my own water company and I clean out my well once a year. Keeps me flu free, dude.
While you're out there see if you can find my car.
LOL!!
A prophet indeed! ;)
10-4!
Was it full of gas? ;)
Good Lord! Does this mean...
For a pandemic to emerge, a human must simultaneously be infected with human influenza and avian influenza, Mattos argued.
This is absolutely untrue. The virus, which is endemic in Asia, can recombine with another influenza virus capable of infecting humans in swine or other farm mammals. It COULD happen in humans, or in any number of other animals which can pass viruses to humans.
Every year, waterfowl and swine in China share viruses which they pass to humans and which become each year's HUMAN influenza virus. The most predominant one(s) become the basis for the flu shot developed every year.
At this particular time, waterfowl have been shown to be able to harbor the H5N1 virus without becoming sick. Meaning they'll stay alive to infect pigs, and since both species live in close proximity to humans in China--in some cases share the same house--the mutation of H5N1 into a form easily passed between humans is inevitable.
I simply cannot believe that a statement so irresponsible and ignorant as Bill Mattos' was published by any newspaper anywhere, but then I read that it is the Modesto Bee, and my incredulity becomes sad understanding.
Bill Mattos may believe that since no birds have been found in the lower 48 that have tested positive for H5N1, he's safe. Well, the next time he shakes hands with a delegation from the Guangdong province in China, come to see the egg production methods of the California Poultry Association, he may find that migratory birds aren't the only concern, here...
Sheesh!
Recall last year both England and America ran out or never had enough regular flu shots. One dose in England was also contaminated. It didn't matter since I got some sort of flu a little before the so-called flu season gets under way. I believe it's far better to be prepared then real sorry one did not.
My own doctor considers the situation potentially very serious and was concerned by our government's foot dragging on this medical matter. He has advised accordingly to take precautions now.
Are there any specific precautions that your doctor advises?
Excellent point. I shall query that little basta ... I mean ... know it all and get to the bottom of this. ;)
I'd have evacuated from New Orleans, but I couldn't let go of this here bus sign.
This story comes out every year around this time.
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