Let me clarify, and please allow me to step away from "macro" and "micro" since those terms may have baggage.
In a lot of discussions about ToE, someone will bring up an experiment in which a population of fruit flies was created to all have a specific trait. The starting population did not have that trait, but the current population certainly does. Voila! Evolution confirmed in the lab!
I was merely trying to point out that a new specicies is not described in the above paragraph. The Origin of Species is not of great interest if it discusses red hair or blue eyes (allele variation within a population, I believe is the term).
The real meat of ToE is when one species gives rise to a new species which can no longer interbreed with the original species. Ring species are of interest here.
But to reiterate the point I was trying to make. In a lab, a chemist can absolutely substantiate Avogadro's law. As often as you like. But a biologist cannot great a new species, and thereby substantiate ToE in a controlled laboratory setting.
Substantiating ToE cannot be done in the same way as the laws of physics of chemistry can be substantiated.