Posted on 05/31/2005 12:09:14 PM PDT by Judith Anne
This is the Marburg Surveillance Project Thread II.
This thread, as the first one was, will be used for all of the latest Marburg Outbreak News and comments. This is the place to post all comments about the Marburg outbreak, all articles and links to articles about the Marburg outbreak.
Thanks. (BTW, there is a wafer fab in 'Bama)
[best Bugs Bunny voice] Ahhh, could be, doc.
Is it over??? Here is Dick Thompson from CDC saying its NOT under control...
Angola's Marburg Epidemic Slows
June 1, 2005 -- The outbreak of dangerous Marburg fever in Angola is tapering off. But the World Health Organization says it's way too soon to declare the epidemic over.
More than 400 people have fallen sick with Marburg fever since the WHO began counting in March. More than 335 have died. The numbers of new cases have fallen, but they're still emerging. Health workers are especially troubled by four cases in Bongo, a town some distance south of the epicenter in the city of Uige. Those cases have no known connection to anybody from Uige.
Even if no more cases emerge, WHO spokesman Dick Thompson says it will be weeks before the epidemic can be declared over.
"We think that all the systems are in place to bring this to an end," Thompson said. "But we're 42 days from the end of it under the best of circumstances." Forty-two days is twice the maximum incubation period of Marburg. -- Richard Knox
http://www.npr.org/templates/story/story.php?storyId=4679436
No news on Ebola either...mighty suspicious to me!
OOPS!!! Too early for me!!! I meant Dick Thompson from the WHO! ... WHOOOOOOOOOOOOOOOOOOOOOOOOOOOOO... sorry!
Hmmmm, not on the web yet. July issue?
No kidding? Where?
Yes.
Huntsville. At the university...
yeah, sure... it's time to go back to our mowers, beer, and barbecues, nothing to see here...
going from 2ndreconmarine's analysis on MSP#1, I'd be inclined to suppose that the only way the outbreak could have become contained is if everyone ran like hell from the hot zone.
Do you know what kind of photo printer they use? Contact, projection, e-beam or 5x/10x steppers?
From www.nmdc.uah.edu
1. GCA XLS i-line stepper
2. Mask Aligner: AB-Manufacturing, 8” x 8” exposure area and backside alignment.
3. Nanometer Pattern Generation System for e-beam lithography.(NPGS v.8.0, JC Nabity Lithography Systems)
4. E-beam lithography based on a LEO 1550 field emission scanning electron microscope equipped with a beam blanker.
5. Interferometric lithography: Custom system with fringe locking (442 nm HeCd source).
I'm told the GCA is down...
MARBURG HEMORRHAGIC FEVER - ANGOLA (46) *************************************** A ProMED-mail post ProMED-mail is a program of the International Society for Infectious Diseases Date: Mon 30 May 2005 From: ProMED-mail Source: Medecins sans Frontieres, Mon 30 May 2005 [edited]
Angola: Marburg epidemic continues to spread fear in the north
Feeling hopeless against the Marburg epidemic that has gripped their region, inhabitants of the Angolan city of Uige are either suffering in silence, expressing their anger, or fleeing their homes. Marburg fever has already claimed the lives of more than 280 people in the province, and new cases are surfacing almost every day.
Faced with a disease that can be transmitted by the simplest contact with an infected and symptomatic person, the 200 000 or so city-dwellers of Uige want to know who is responsible, and sometimes their fears turn into wrath. Stones have been thrown at international teams who are fighting against the epidemic but cannot treat patients, as no cure exists; the only measure they can take is to isolate infected persons to avoid further transmission.
As patients who enter the hospital very rarely come out alive, families are refusing to abandon their sick and prefer to keep them hidden at home, exposing themselves to the risk of being the next victims.
Day after day, one woman visited her husband at the Marburg treatment center of the Uige Provincial Hospital. But back in the barrio (or neighborhood) of Camdombe Velho, she did not dare tell her neighbors why her husband was sick. "If I told them what he has, they would not approach my house," she said. After spending 13 days in the center, her husband no longer had symptoms, and he recently returned home. He is one of the 1st isolated patients who appears to have won the battle against the disease.
Yet for many Uige inhabitants, the provincial hospital remains synonymous for death. Not only because almost none of the confirmed cases have survived, but also because the hospital has been one of the main focal points of the outbreak. At 1st, children in the pediatric ward died; then their mothers died; health staff followed - 16 lost their lives; and the disease spread on to the staff's relatives.
"People always look for someone to blame for such deaths," said Pastor Alberto Moises, while watching team members from MSF and WHO collecting a body in the barrio of Pedreira. "They say that Marburg is in the hospital; that there is a large reservoir of blood there; and that anyone who approaches it dies," he explained. "Many people have fled to Luanda (the capital) or to the villages."
"It's very frustrating," said Diana Pou, an MSF doctor. "We can only wash the patients, give them food and drinks, and treat their symptoms." "We have to tell ourselves that we are here to deal with a public health problem, and we have to get away from a personal approach. The primary goal is to isolate infected persons so that they don't infect others," adds Luis Encinas, the medical coordinator.
Convincing the population that isolation is necessary is a Herculean task. An MSF team recently organized a meeting with representatives of the Pedreira barrio. The importance of having cases come to the hospital -- even though no treatment is yet available -- was discussed for hours. Then a traditional healer spoke up: "I have a cure. And I have cured 5 people," he claimed, without being able to name any of the 5. Suddenly, all the participants at the meeting -- including those who had seemed most convinced of the need to isolate cases -- began demanding that the traditional healer's cure be applied. 2 short sentences had reversed the meeting's progress.
In addition to such setbacks, local traditions and customs can become lethal. In preparation for a burial ceremony in the barrio of Ngana Camana on 10 Apr 2005, the body of a woman was washed by her sister, her sister-in-law, and her godchild. All 3 women subsequently died of Marburg fever.
"If we prove that [she] was infected, it is clear that the virus may have been passed on when her body was washed," said Evelyn Depoortere, an epidemiologist at Epicentre. Dr. Depoortere is also looking into the possibility that the woman belongs to a cluster of 5 people, all from Ngana Camana, who may have contracted Marburg at the local health center. A WHO team noted that needles in this center were being re-used after soaking for only a few minutes in warm water.
"If you compare it to AIDS," said Josefa Rodriguez, an MSF psychologist, "in Europe, after years of awareness-raising, we have managed to change some behaviors. Here, we need people to change their customs in 2 weeks. And no matter how hard we try, it's very hard to succeed in doing that."
In the meantime -- and despite the fact that new cases are registered almost every day -- the inhabitants of Uige are returning little by little to a semblance of normality. The streets, virtually deserted some weeks ago, have gradually filled up again. People no longer cover their mouths with horror when teams collecting bodies pass by. Accustomed to many other hardships, the population is showing signs of stoicism.
"In Angola, we have known war," said Ligia Maria Costa Pedro, head of the pediatric ward in the Uige hospital, "and we have come out of it and moved on. Even though Marburg is killing a lot of people, there will always be a few survivors." She lost 7 of her colleagues to Marburg.
-- [Recent reports from Angola have expressed, alternately, hope and despair. The absence of quantitative information on cases and fatalities in the MSF report above makes it difficult to evaluate the state of current progress in containing the outbreak. One can only admire the dedication and courage of those striving to achieve a successful outcome. - Mod.CP]
Thanks. They're not to far behind the industry. We used to donate our obselete equipment to the University Of Houston.
http://www.sterlingtimes.co.uk/sambo.htm
Little Black Sambo
Marburg epidemic spreads fear in the north Angola, MSF
30 May 2005
In one of the rudimentary buildings on the hospital grounds, an MSF team has set up a treatment center for Marburg patients. Covered from head to toe in bio-security suits, the team members are working in extreme conditions. In addition to the inevitable fear and the intense heat they must endure, their role is limited to accompanying patients to their near-certain death.
Feeling hopeless against the Marburg Epidemic that has gripped their region, inhabitants of the Angolan city of Uige are either suffering in silence, expressing their anger, or fleeing their homes. Marburg - the hemorrhagic fever that resembles Ebola - has already claimed the lives of more than 280 people in the province, and new cases are surfacing almost every day.
Faced with a disease that can be transmitted by the simplest contact with an infected and symptomatic person, the 200,000 or so city-dwellers of Uige want to know who is responsible, and sometimes their fears turn into wrath. Stones have been thrown at international teams who are fighting against the epidemic but cannot treat patients, as no cure exists; the only measure they can take is to isolate infected persons to avoid further transmission.
As patients who enter the hospital very rarely come out alive, families are refusing to abandon their sick and prefer to keep them hidden at home, exposing themselves to the risk of being the next victims.
Day after day Zita visited her husband Horacio at the Marburg treatment center of the Uige Provincial Hospital. But back in the barrio (or neighborhood) of Camdombe Velho, she did not dare tell her neighbors why her husband was sick. "If I told them what he has, they would not approach my house," said Zita.
After spending 13 days in the center, Horacio no longer had symptoms and he recently returned home He is one of the first isolated patients who appears to have won the battle against the disease.
Yet for many Uige inhabitants, the provincial hospital remains synonymous of death. Not only because almost none of the confirmed cases have survived, but also because the hospital has been one of the main focal points of the outbreak. At first children in the pediatric ward died; then their mothers died; health staff followed - 16 lost their lives; and the disease spread on to the staff's relatives.
"People always look for someone to blame for such deaths," said Pastor Alberto Moisés, while watching team members from Médecins Sans Frontières (MSF) and the World Health Organization collecting a body in the barrio of Pedreira. "They say that Marburg is in the hospital; that there is a large reservoir of blood there; and that anyone who approaches it dies," he explained. "Many people have fled to Luanda (the capital) or to the villages."
In one of the rudimentary buildings on the hospital grounds, an MSF team has set up a treatment center for Marburg patients. Covered from head to toe in bio-security suits, the team members are working in extreme conditions. In addition to the inevitable fear and the intense heat they must endure, their role is limited to accompanying patients to their near-certain death.
"It's very frustrating," said Diana Pou, an MSF doctor. "We can only wash the patients, give them food and drinks, and treat their symptoms."
"We have to tell ourselves that we are here to deal with a public health problem, and we have to get away from a personal approach. The primary goal is to isolate infected persons so that they don't infect others," adds Luis Encinas, the medical coordinator.
Convincing the population that isolation is necessary is a Herculean task. An MSF team recently organized a meeting with representatives of the Pedreira barrio. The importance of having cases come to the hospital - even though no treatment is yet available - was discussed for hours.
Then a traditional healer spoke up: "I have a cure. And I have cured five people" he claimed, without being able to name any of the five. Suddenly all the participants at the meeting - including those who had seemed most convinced of the need to isolate cases - began demanding that the traditional healer's cure be applied. Two short sentences had reversed the meeting's progress.
Beyond such setbacks, local traditions and customs can become lethal weapons. In preparation for a burial ceremony in the barrio of Ngana Camana on April 10th, the body of a woman named Madalena was washed by her sister Ana, her sister-in-law Lisa, and her godchild Elisabeth. All three women subsequently died of Marburg.
"If we prove that Madalena was infected, it is clear that the virus may have been passed on when her body was washed," said Evelyn Depoortere, an epidemiologist at Epicentre. Evelyn is also looking into the possibility that Madalena belongs to a cluster of five people, all from Ngana Camana, who may have contracted Marburg at the local health center. A WHO team noted that needles in this center were being re-used after soaking for only a few minutes in warm water.
"If you compare it to AIDS," said Josefa Rodríguez, an MSF psychologist, "in Europe, after years of awareness-raising, we have managed to change some behaviors. Here we need people to change their customs in two weeks. And no matter how hard we try, it's very hard to succeed in doing that."
In the meantime - and despite the fact that new cases are registered almost every day - the inhabitants of Uige are returning little by little to a semblance of normality. The streets, virtually deserted some weeks ago, have gradually filled up again. People no longer cover their mouths with horror when teams collecting bodies pass by. Accustomed to many other hardships, the population is showing signs of stoicism.
"In Angola we have known war," said Ligia María Costa Pedro, head of the pediatric ward in the Uige hospital, "and we have come out of it and moved on. Even though Marburg is killing a lot of people, there will always be a few survivors."
She lost seven of her colleagues to Marburg.
There is an article in the NYT today about possible vaccines for Marburg and Ebola. One candidate is a recombinant manipulation of the vesicular stomatitis virus,which affects cattle.
I don't know if link will work ( I believe you have to be a subscriber), but here 'tis.
http://www.nytimes.com/2005/06/05/health/05cnd-virus.html?pagewanted=1&ei=5094&en=008f04349c604d5e&hp&ex=1118030400&partner=homepage
Here's another link from Reuters,via CNN:
http://www.cnn.com/2005/WORLD/africa/06/05/vaccine.reut/
The current trend curve is everyone dead in 4.3 years.
The data would suggest that instead of 100 percent chance of dying, they would have an 80 percent chance of survival,"
BIG improvement!
If you could use this vaccine in the field and vaccinate family members of known cases, you could be protecting those people who are putting their lives at risk for their loved ones," Jones said.
Five to 21 day incubation period, 28 days to protection.
Jones said trials demonstrated protection in 28 days, but speculated the vaccines could work in half that time.
OooooKay, Five to 21 day incubation period, 14 days to protection. Now it's looking a bit better.
Right now, it's too little, too late and too slow.
Still, it's the best news so far...
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