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Yes, the same is basically true of any cell that you culture outside of the body. We don't necessarily know of all the growth factors they need to group and develop properly. Also, we are putting them under selection pressures that favor cells that divide rapidly. Manipulation of the DNA damages it in often unintended ways. By the time you put it back into the body, you really have changed it in many ways, many of them undetectable. And you can't really practically sequence its whole genome before you do, to make sure that you've only changed the things you wanted.

Can anyone tell me when was the last great breakthrough in medicine that didn't do extensive higher mammalian research/trials BEFORE moving to humans? ... What is the rush to commit cannibalism on human life before proving methodologies with other mammalian models? Folks, this entire rush to cannibalism that Specter sees as 'enlightened medical advancement' is demonic in nature. What will be left of our 'fear of God' when we are extending our lives via cannibalism? We will no longer be growing in Grace and Knowledge, we will be spitting in God's face. This road Specter wants this nation upon with all haste is but the starting gate for the euphemistically named 'therapeutic cloning' and tissue banks held by grand corporations. Evil is strutting boldly with men like Arlen Specter to do its work. And this is not a new direction for Specter for he's been in Harkin's pocket for years as proved during the appropriations hearings of years ago when Harkin chaired the committee and wanted funding for ESCR under Clinton's watch ... and of course the degenerate sinkEmperor opened the door then through NIH.