If the feds are going beyond their constitutional limits, by all means, YES. Congress has so defiled its constitutional responsibilities that I think the states should stand up & say NO MORE!
But the problem is that the feds have addicted state governments to getting their piece of the federal pie that they cannot help but keep their hand out asking for more federal highway funds, & on & on. I'd like to see the states begin to refuse to pay federal gas & other taxes until the feds quit abusing its authority, but that ain't gonna happen.
Well, RP, if you are truly being honest & aren't so concerned about our wanting to "smoke dope to our heart's content", like you say you are, then please--LEAVUS US ALONE & QUIT PUSHING FEDERAL POLICIES THAT TREAT US LIKE CRIMINALS...or confiscate our property, vehicles, kids, etc., or have us fired from our jobs when we use responsibly.
We are NOT a threat to you, RP: that is the LAST thing we wanna do, because we just wanna live our lives just like you wish to live yours (to pursue life, liberty, & happiness in our/your own way). We are willing to extend our hand of friendship to you, so why must you insist on throwing us in jail????