He also mistakenly thought that my calculation required all 6 to occur simultaneously. The calculation only assumes that they occurred within 30 years and that there is no selection for any combination other than the correct 6." Spetner
Depending on the bug, I could do those 47 amino acid changes in about 6 months, so 6 is a piece of cake. This would use modern molecular biology techniques. To use only "natural" mutational events, it might take a year or two.
The point is well taken that you cannot determine probability based on 6 mutations all occurring at one time in one bug. However, given that the average bacterial culture contains 1,000,000,000 bacteria per ml, a liter would have 1,000,000,000,000 bacteria. An average mutational rate of 1/1,000,000, means that there are 1,000,000 mutants in a liter of bacteria. Digest these numbers and you will see how easy it is to get to a nylon eating bug in a short period of time.
I'm just *dying* to see exactly how he calculated that alleged "probability"...
It's highly suspicious that Spetner just tossed the number out without even a hint of what sort of math he used.
And any number that freakin' low for "six mutations in 30 years" in bacteria (which mutate at the drop of a hat, and have mind-bogglingly large populations and reproductive rates) seems patently bogus on its face.
Jwalsh07, would you care to email Spetner and ask to see his calculations? I can't find a recent reference to an email address for Spetner (he doesn't even seem to have a homepage or a faculty page anywhere), but lspetner@alum.mit.edu worked as of several years ago (no clue if still does).