Free Republic
Browse · Search
News/Activism
Topics · Post Article

To: neverdem

Low-Dose Aspirin Therapy

References


Citations
Awtry EH, Loscalzo J (2000). Aspirin. Circulation, 101: 1206–1218.

Danchin N, et al. (2002). Acute myocardial infarction. Clinical Evidence (7): 11–35.

Sudlow C, et al. (2003). Stroke prevention. Clinical Evidence (9): 221–243.

Kurth T, et al. (2003). Inhibition of clinical benefits of aspirin on first myocardial infarction by nonsteroidal antiinflammatory drugs. Circulation, 108: 1191–1195.


33 posted on 01/22/2005 9:16:28 PM PST by Maynerd
[ Post Reply | Private Reply | To 32 | View Replies ]


To: Maynerd; All
Maybe your not getting the gist of my question. The reference to the Awtry EH, Loscalzo J (2000). Aspirin. Circulation, 101: 1206–1218. article recommends

"160 to 325 mg for acute treatment of cardiovascular events and 75 to 160 mg/day for primary and secondary prevention" (By which mg/d means milligrams per day. Scroll down the link halfway, just before the references.)

Primary prevention means before you have the first acute myocardial infarction or ischemic stroke. Secondary prevention's intention is aimed at preventing a recurrence.

You wrote a baby aspirin every other day in your previous comment. Your second reference, "Danchin N, et al. (2002). Acute myocardial infarction. Clinical Evidence (7): 11–35.", has nothing to do with the prevention of acute myocardial infarction or ischemic strokes. That citation was obtained from this link's URL. It describes treatment after it happened, not prevention.

I was unable to find the article referenced in your next reference, "Sudlow C, et al. (2003). Stroke prevention. Clinical Evidence (9): 221–243", but in the search I found this recommendation, The optimal aspirin dosage for use in the prevention of stroke or TIA remains controversial, but a range of 50 to 325 mg per day has been recommended which comes from the 3rd reference of Transient Ischemic Attacks: Part II. Treatment

Does your last reference to Kurth T, et al. have anything to do with daily dosing versus every other day dosing? I am aware that other NSAIDs can interfere with the irreversible inhibition of platelet aggregation by aspirin in 75 - 80 percent of patients.

Limiting the search to practice guidelines, the only article that I could find was Antithrombotic therapy for coronary artery disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy., which recommended "For primary prevention in patients with at least moderate risk for a coronary event, we recommend aspirin, 75 to 162 mg/day".

35 posted on 01/23/2005 1:47:25 AM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
[ Post Reply | Private Reply | To 33 | View Replies ]

Free Republic
Browse · Search
News/Activism
Topics · Post Article


FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson