I won't flame you. I think any caliber larger than .22 (and if that's all you have at the moment of need, it is much better than nothing) when used at point-blank (or near point blank) range is going to do the job. I own several pistols chambered in .40 S and W and a Glock 17 in 9 mm. I just like the idea of a bigger hole in the perp, since I really don't want to have to shoot him more than once. Still, a single round of .40 in the upper torso is going to have a startling and surprising effect on any assorted vermin.
You, my friend, have a gift for understatement. :)
"... Still, a single round of .40 in the upper torso is going to have a startling and surprising effect on any assorted vermin...."
As retired LEO & Range Master, we used to say the bigger the hole the faster you let the air out. Cheers.