She will run. It's her last chance at a lifelong dream beyond the grasp of nearly all others.
She will lose. Unsympathetic historians have been diligently gathering & publishing dirt on her for 12 years (16 by the target election). The "Hillary Must Lose" side will make the "Bush Must Go" team look tame. She can't survive a regular electoral race.
She missed her chance. 2004 was the best opportunity: with Kerry melting & flubbing, she should have pulled all strings & favors to swap him out and her in within 60 days of the election, giving her supporters an emotional rush and her detractors silenced by confusion coupled with McCain-Feingold.
Kerry was opposed only for about 4 months.
Hillary's opponents are moving to oppose her for 4 years.
Having no inherent winning message, she can't uphold the political fight that long.
Lady Macbeth.
She activates a deep and visceral contempt that can't even be articulated into words.
The democrats would be giving the GOP an early Christmas present if they decided to nominate Hillary Clinton for president four years from now.
I'd like to think she'd be a sure loser, but four years is a long time to look ahead in politics (who in 1972 thought that the 1976 race would be between Gerald Ford and Jimmy Carter?). About 2007 if it looks like Hillary can't be stopped from getting the nomination but is likely to lose the election we might see a lot of panic on the Democrat side...they would be looking at another 4 or 8 years in the wilderness.