Yes. I own all of the big bores that we took to the range. I shoot them regularly. I reload for all of those cartridges. At $35 for 12 rounds of most S&W 500 Mag, you would be in the poor house if you didn't reload. I have smaller stuff in .44 Mag and .41 Mag. I'm still looking for a box of the Corbon 440 hardcast (2582 ft-lbs at the muzzle). Most shops don't carry it.
If I was really in a frivolous frame of mind, I would purchase the 4" S&W 500 Magnum. Even so, I would fire anything other than the 275 gr Corbon in that model.