Possibly. It became a leading text for the abolitionist movement, and help to publicize the conditions of American Blacks like no book did until Ralph Ellison's
Invisible Man. However the leading texts guiding the abolitionist movement as well as other social movements of the nineteenth and early twentieth century-womens sufferage, temperance, and the like-were pamphlets, not books per se, which is why many seminal texts (such as Ida B. Wells' pamphlet criticizing the Chicago World's Fair) were probably omitted.
The Jungle by Upton Sinclair should probably also be included, as it launched not only a movement which reformed the meat-packing industry and enforced safety regulations on other industries, but initiated a new form and style of journalism which remains dominant. Its influence has been for both good and ill.