When faced with this issue the only metaphysically naturalist appeal remaining is "anthropic principle" which is kinda like covering one's ears and singing loudly.
That hardly seems unreasonable, if you find it more convenient or more accurate to think of it in those terms.
I personally believe that naturalistic/materialistic theories - all strongly deterministic theories - also point to a creation despite all their objections to the contrary. I say this because all of the theories require a beginning - even imaginary time theory, multi-verses and ekpyrotic cosmology.
Possibly. Perhaps some things are simply not knowable to us. Yet. ;)