The location for this most famous dark nebula is in Orion's belt, near the easternmost star Zeta Orionis (Alnitak). The Horsehead's designation is B33.
Took my first scope, a 3" reflector, out to try to spy the Horsehead Nebula. Nothing.
Years later took my homemade 6" reflector out to try to see the Horsehead Nebula. Nothing.
Takes more than that. The Horsehead Nebula is tiny and dim.
Of course that all was back in the old days when it was possible to get a clear, dark sky now and then.