The highest percentage of smokers in the U.S. was about 42.4%, in the early 60's, so not everyone was.
Smokers were 2.6% in the U.S. in 1900. The big difference was the U.S. government promoted smoking. They gave U.S. soldiers cigarettes in World War I. The in the 1920's, it was promoted as feminist for women to smoke.
By the way, they already knew smoking tobacco was bad for you by the time of Shakespeare.