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Long-term use of melatonin supplements to support sleep may have negative heart health effects
Medical Xpress / American Heart Association's Scientific Sessions 2025 ^ | Nov. 3, 2025

Posted on 11/06/2025 3:00:16 PM PST by ConservativeMind

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The secondary findings sound worse than the primary ones:

A secondary analysis found:

—Participants taking melatonin were nearly 3.5 times as likely to be hospitalized for heart failure when compared to those not taking melatonin (19.0% vs. 6.6%, respectively).

—Participants in the melatonin group were nearly twice as likely to die from any cause than those in the non-melatonin group (7.8% vs. 4.3%, respectively) over the five-year period.

I have taken melatonin for most of a year, several years back.

I wonder what awaits.

1 posted on 11/06/2025 3:00:16 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

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2 posted on 11/06/2025 3:00:43 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Rest assured, this is a correlation study.

One has to ask, why are they having trouble sleeping and feel the need to take melatonin?

Therein lies the root cause, not the melatonin.


3 posted on 11/06/2025 3:04:27 PM PST by Blueflag (To not carry is to choose to be defenseless.)
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To: ConservativeMind

I’ve been taking it for 5 years


4 posted on 11/06/2025 3:04:37 PM PST by ThisLittleLightofMine
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To: ConservativeMind

I took melatonin a few times in the 90’s, but I decided to stop. The reason being is that it is a hormone, and I realized scientists still do not know enough about hormones to tell us what is safe and what is known. The only hormone I try to condone is Vitamin D - because some of us can’t get enough otherwise. Ideally, we could get enough from sun and food.


5 posted on 11/06/2025 3:07:45 PM PST by nickcarraway
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To: Blueflag

It was matched to people who had insomnia, but had used prescriptions or other methods, and not melatonin.


6 posted on 11/06/2025 3:08:03 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I’ve been taking it since 2023. I’ve been trying to wean myself off of it and now I’m down to just 3MG at night, down from 12 MG.


7 posted on 11/06/2025 3:15:18 PM PST by ducttape45 (Jeremiah 17:9, "The heart is deceitful above all things, and desperately wicked: who can know it?")
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To: ConservativeMind

How much melatonin does one have take to trigger these adverse effects?


8 posted on 11/06/2025 3:19:10 PM PST by theoilpainter
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To: ConservativeMind

Jack Daniels works great.


9 posted on 11/06/2025 3:19:29 PM PST by Mark (DONATE ONCE every 3 months-is that a big deal?)
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To: Blueflag

Good point. Melatonin is also one of the recommended supplements for fighting long covid vaccine.


10 posted on 11/06/2025 3:23:38 PM PST by Cold Heart
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To: ConservativeMind

I periodically take melatonin or tea that has melatonin. I will throw every into the garbage now.


11 posted on 11/06/2025 3:32:32 PM PST by KittyKares
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To: ConservativeMind

I went to the link and could find nothing about when this study was conducted, the number of people in the two groups, or any link to the original study. Am I wrong?
So happy to know this study can single out the cause of heart failure, especially after you may be on multiple other prescriptions or have been quadruple Jabbed if this study occurred after Dec2020. Studying people who were prescribed melatonin by their doctor vs OTC supplements without doctor involvement is another question.
Yes, indeed, why do we need sleep aids these days??? The last 5, 10 years have been so blissful in our Realm. 🤔


12 posted on 11/06/2025 3:34:06 PM PST by Jarvis Law 2.0
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To: Jarvis Law 2.0

Okay- I do see how many people were included in this international study without identifying the sample by country.


13 posted on 11/06/2025 3:38:44 PM PST by Jarvis Law 2.0
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To: ConservativeMind

It doesn’t work as a sleep aid for me after the first night or two.


14 posted on 11/06/2025 3:42:17 PM PST by IndispensableDestiny
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To: Blueflag
Among adults with insomnia, those whose electronic health records indicated long-term melatonin use (12 months or more) had about a 90% higher chance of incident heart failure over five years compared with matched non-users (4.6% vs. 2.7%, respectively).

Both the melatonin users and the non-melatonin users had trouble sleeping.

15 posted on 11/06/2025 3:44:53 PM PST by heartwood (Please blame all ridiculous or iinappropriate words on autocorrect. Thank you. )
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To: ConservativeMind

apparently a PRELIMINARY correlation study that wasn’t published, but just presented at a conference ...

a correlation study apparently based just on prescription records, but no indication of the effect of dosage, which can range from 100 mcg to 10,000 mcg ...

no information at all can be obtained from the reference link to the conference in the medicalxpress article: https://exhibitatsessions.org/scientific-sessions/

the whole article is based on information that cannot be independently verified by the reader ...


16 posted on 11/06/2025 3:48:48 PM PST by catnipman ((A Vote For The Lesser Of Two Evils Still Counts As A Vote For Evil))
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To: ConservativeMind

Correlation or causation?


17 posted on 11/06/2025 3:50:27 PM PST by HereInTheHeartland (“I don't really care, Margaret.””)
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To: ConservativeMind

A very unhelpful article. “People who had been using melatonin for at least a year”. At what frequency? Daily? Occasional? Every 6 months? And at what dosage?

This was clearly written to scare people who take or are considering taking melatonin.


18 posted on 11/06/2025 4:04:10 PM PST by motor_racer (Who will bell the cat?)
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To: Mark

As does a turkey sandwich.


19 posted on 11/06/2025 4:06:31 PM PST by piasa (Attitude adjustments offered here free of charge)
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To: ConservativeMind

Magnesium Glycinate 30-60 minutes before bed is the healthiest sleep supplement


20 posted on 11/06/2025 4:07:03 PM PST by Mozzafiato
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