It appears colesevelam is the better drug from a side effect and efficacy view.
I thought it said PEAS… was trying to figure out why it’s an issue. LOL!!
This Swedish study showed that cholestyramine and colesevelam, both bile acid sequestrants, reduced serum PFAS (especially PFOS) by about 40% in 12 weeks by blocking enterohepatic recirculation and trapping PFAS in the gut for fecal excretion.
How it works: Cholestyramine and colesevelam are cationic resins that bind negatively charged bile acids in the small intestine. PFAS (like PFOS, PFHxS, and PFOA) are anionic and amphiphilic, similar to bile acids. So these resins trap PFAS in the gut, preventing their reabsorption via the enterohepatic cycle — forcing them out in feces.
Natural alternatives: No natural substance has yet been shown in human trials to lower PFAS like cholestyramine or colesevelam, but some may act through comparable bile-binding or adsorption mechanisms. Chlorella is the strongest natural analog, having shown limited human PFAS-binding benefit when used with cholestyramine. Soluble fibers like psyllium or oat beta-glucans, which can bind bile acids and might modestly enhance PFAS fecal elimination. Unproven but interesting are activated charcoal and clays, which could adsorb PFAS, but they lack targeted human data.
Caveats: Natural agents would likely have weaker effects than cholestyramine/colesevelam. Long-term use of bile-binders can reduce fat-soluble vitamin absorption (A, D, E, K) and interfere with drug uptake.
Need more chemicals to remove some chemicals, so a few people can make money along the way.
PFAS is good. You need less embalming fluid when the time comes. Like internal Saran Wrap.
Overview of PFAS in Water
Per- and polyfluoroalkyl substances (PFAS), often called “forever chemicals,” are synthetic compounds used in various products like waterproof clothing, food packaging, and firefighting foams. They are persistent in the environment and can contaminate water sources.
Sources of PFAS Contamination
PFAS can enter water supplies through:
Industrial Discharges: Wastewater from manufacturing facilities.
Landfills: Leachate from landfills containing PFAS products.
Firefighting Foam: Runoff from training sites or incidents where PFAS-containing foams were used.
Health Risks Associated with PFAS
Exposure to PFAS in drinking water has been linked to several health issues, including:
Increased cholesterol levels
Liver damage
Thyroid disease
High blood pressure during pregnancy
Developmental issues in infants
Certain cancers
Detection and Regulation
Recent data indicates that PFAS contamination is widespread. In the U.S., over 172 million people are served by water systems with detectable PFAS levels. Regulatory bodies like the Environmental Protection Agency (EPA) have begun to establish limits for PFAS in drinking water, with new standards requiring monitoring and treatment by 2027.
Treatment Options for PFAS Removal
To reduce PFAS levels in drinking water, several treatment technologies can be employed:
Treatment Method Description
Activated Carbon Filtration. Removes PFAS by adsorption onto carbon media.
Reverse Osmosis Uses a membrane to filter out PFAS from water.
Ion Exchange. Exchanges PFAS ions with less harmful ions.
These methods can be installed at the point of use, such as kitchen faucets, or at the point of entry to homes.
For those concerned about PFAS in their water, testing and treatment options are available through local health departments or water authorities.